Oligonucleotide analogs having modified dimers
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United States of America Patent
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Jul 16, 2002
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app pub date -
Aug 7, 1998
filing date -
Jun 6, 1995
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Abstract
Modified dimers having a ribose sugar moiety in the 5' nucleoside and a 2' modified sugar in the 3' nucleoside are provided. The modified dimers are useful in the preparation of oligonucleotide analogs having enhanced properties compared to native oligonucleotides, including increased nuclease resistance, enhanced binding affinity and improved protein binding.
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