Synthesis and clinical uses of D,.alpha.-tocopherol nicotinate compounds
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United States of America Patent
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Jul 23, 2002
Grant Date -
N/A
app pub date -
Mar 20, 2000
filing date -
Apr 7, 1999
priority date (Note) -
Expired
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Abstract
A process of synthesis of D,.alpha.-tocopherol nicotinate compounds is presented. Therapeutic uses for this compound are described. The active agents are demonstrated to be complementary in their physiological functions especially as these relate to cellular and endothelial biochemistry and physiology and, ultimately to vascular health. The active components of the invention are selected for inclusion in a unique combination that clinically reduces risks of vasculopathy, DNA strand breakage and neuronal excitotoxicity in various diseases. In addition to the systemic vascular benefits acquired, improvement of the vascular health of the eye reduces the risk of glaucomatous optic nerve atrophy with its accompanying visual field loss and potential blindness and reduces conditions of risk for macular degeneration.
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