Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair
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United States of America Patent
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Aug 6, 2002
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app pub date -
May 17, 2000
filing date -
Aug 19, 1999
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Abstract
Methods and compositions for directing adipose-derived stromal cells cultivated in vitro to differentiate into cells of the chondrocyte lineage are disclosed. The invention further provides a variety of chondroinductive agents which can be used singly or in combination with other nutrient components to induce chondrogenesis in adipose-derived stromal cells either in cultivating monolayers or in a biocompatible lattice or matrix in a three-dimensional configuration. Use of the differentiated chondrocytes for the therapeutic treatment of a number of human conditions and diseases including repair of cartilage in vivo is disclosed.
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