Measurement of gastric emptying using stable isotopes
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United States of America Patent
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Aug 13, 2002
Grant Date -
N/A
app pub date -
Oct 20, 2000
filing date -
Oct 20, 2000
priority date (Note) -
Expired
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Abstract
The invention provides a diagnostic test for gastrointestinal disorders by providing a safe, convenient, reliable method for measuring gastric emptying. In this test, a tracer amount of .sup.13 C-glutamine or .sup.13 C-glutamic acid is added to a liquid meal, or .sup.13 C-glutamic acid added to a solid meal. After digestion in the stomach, the meal is emptied into the small bowel, where the labeled .sup.13 C-tracer is immediately taken up and metabolized by the cells lining the small bowel. The released .sup.13 CO.sub.2 is detected in the breath. The measurement of rise in the level of .sup.13 CO.sub.2 as a function of time is correlated to the rate of gastric emptying.
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