Compounds and methods for inhibiting cancer metastasis
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United States of America Patent
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Aug 13, 2002
Issued Date -
N/A
app pub date -
May 5, 1999
filing date -
May 5, 1998
priority date (Note) -
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Abstract
Agents for inhibiting cancer metastasis are provided. The methods comprise administering to a patient an antimetastatic agent that comprises one or more of: (a) a peptide sequence that is at least 50% identical to an OB-cadherin CAR sequence; (b) a non-peptide mimetic of an OB-cadherin CAR sequence; (c) a substance, such as an antibody or antigen-binding fragment thereof, that specifically binds an OB-cadherin CAR sequence; and/or (d) a polynucleotide encoding a polypeptide that comprises an OB-cadherin CAR sequence or analogue thereof.
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