Erythromycins and process for their preparation
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United States of America Patent
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Aug 20, 2002
Grant Date -
Jan 10, 2002
app pub date -
Jun 29, 2001
filing date -
Jul 5, 1996
priority date (Note) -
Expired
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Abstract
Erythromycins, particularly ones with novel C-13 substituents R1 (e.g. C.sub.3 -C.sub.6 cycloalkyl or cycloalkenyl groups) are prepared by fermenting suitable organisms in the presence of R.sub.1 CO.sub.2 H. A preferred organism is Saccharopolyspora erythraea preferably containing an integrated plasmid capable of directing synthesis of desired compounds.
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