Antigen-containing formulation and methods of use thereof
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United States of America Patent
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Aug 27, 2002
Grant Date -
N/A
app pub date -
Sep 17, 1999
filing date -
Sep 21, 1998
priority date (Note) -
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Abstract
An antigen-containing formulation is provided, comprising: (a) an antigen; (b) a TH1-inducing adjuvants; and (c) a sparingly soluble amino acid or a derivative thereof. The adjuvants may be, for example, monophosphoryl lipid A, 3'-de-O-acetylated monophosphoryl lipid A, derivatives thereof, or any other adjuvants that enhances an individual's TH response to the antigen. Suitable amino acids include tyrosine, tryptophan, derivatives thereof, and the like. Methods for using the formulation are also provided; in a particularly preferred embodiment, the formulation is used as a vaccine.
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