Oligonucleotides having site specific chiral phosphorothioate internucleoside linkages
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United States of America Patent
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Aug 27, 2002
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app pub date -
Jul 14, 1999
filing date -
Jul 14, 1998
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Abstract
Novel chiral compounds that mimic and/or modulate the activity of wild-type nucleic acids are disclosed. In general, the compounds are phosphorothioate oligonucleotides wherein the 5', and the 3'-terminal internucleoside linkages are chirally Sp and internal internucleoside linkages are chirally Rp.
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