Epothilone analogs
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United States of America Patent
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Aug 27, 2002
Grant Date -
N/A
app pub date -
Sep 4, 1997
filing date -
Dec 13, 1996
priority date (Note) -
Expired
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Abstract
Epothilone A, epothilone B, analogs of epothilone and libraries of epothilone analogs are synthesized. Epothilone A and B are known anticancer agents that derive their anticancer activity by the prevention of mitosis through the induction and stabilization of microtubulin assembly. The analogs of epothilone are novel. Several of the anlogs are demonstrated to have a superior cytotoxic activities as compared to epothilone A or epothilone B as demonstrated by their enhanced ability to induce the polymerization and stabilization of microtubules.
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