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Abstract

The instant invention provides compounds of formula I ##STR1## wherein R.sup.1 is OH, O--C(O)--(C.sub.1 -C.sub.6 alkyl), O--C(O)--O(C.sub.1 -C.sub.6 alkyl), O--C(O)--Ar, or O--C(O)--O--Ar; R.sup.2 is H, OH, O(C.sub.1 -C.sub.6 alkyl), O--C(O)--(C.sub.1 -C.sub.6 alkyl), O--C(O)--O(C.sub.1 -C.sub.6 alkyl), O--C(O)--Ar, O--C(O)--O--Ar, O--SO.sub.2 --(C.sub.4 -C.sub.6 alkyl), chloro, fluoro, or bromo; V is S, O, or CH.sub.2 CH.sub.2 ; W is CHOH, C(O), or CH.sub.2 ; X is (CH.sub.2).sub.n ; R.sup.3 and R.sup.4 each, independently, are H, C.sub.1 -C.sub.6 alkyl, C(O)--(C.sub.1 -C.sub.6 alkyl), C(O)--NH--(C.sub.1 -C.sub.6 alkyl), C(O)--Ar, or together with the nitrogen to which they are attached form a 5- or 6-membered imide or cyclic amide; n is 1, 2, or 3; and Ar is optionally substituted phenyl; povided that at least one of R.sup.3 and R.sup.4 contains a carbonyl functional group, and their use in the treatment of estrogen deficiency pathologies.

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First Claim