Zwitterionic-fatty acid compounds having anti-inflammatory properties
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United States of America Patent
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Sep 10, 2002
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app pub date -
Jul 27, 2000
filing date -
Nov 28, 1997
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Abstract
A composition and method for treating both superficial and subdermal inflammation is taught by treating an inflamed skin area, muscle, or bone joint, with a therapeutically effective amount of a skin-compatible ester of a zwitterionic aminosulphonic acid (ZASA-Ester) of the formula. ROCH.sub.2 --CH.sub.2 --N N--CH.sub.2 CH.sub.2 SO.sub.3 M wherein M is an alkali metal, like sodium, and R is a naturally occurring, straight-chain, saturated or unsaturated, aliphatic acid moiety, selected from one of the groups consisting of alkanes, alkenes, and alkadienes, each having a hydrocarbon chain of from one to twenty carbon atoms. The resulting HEPES esters are represented by the acetic acid ester as an exemplary alkane, the oleic acid ester as a exemplary alkene, and the linoleic acid ester as an exemplary alkadiene, the esters of which form fatty acids in nature. The most useful of which are the acetic oleic (cis isomer), linoleic, palmitic, and stearic moieties; they occur naturally as glycerides, i.e., esters of glycerol. Also useful are analogs of HEPES/EPES like piperazine-N'-(2-ethane sulfonic acid); and N-methylpiperazine-N'-(2-ethane sulfonic acid);, and the piperiodine analog of the piperazine ester. A pharmacologic composition is also provided which comprises at least one amphoteric (Zwitterionic-ester) with a pharmacologically-acceptable topical carrier or base. Other adjunctive pharmaceutical agents may be included to facilitate other than topical administration. Also useful are analogs of HEPES/EPES, like Piperazine-N'(2-ethanesulfonic acid; N-Methylpiperazine -N.sup.1 (2-ethanesulfonic acid) and the piperidine analog of the piperazine ester.
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Patent Owner(s)
- HAWKEYE-JENSEN, INC.
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Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
---|---|---|---|
Pugliese, Peter M | Pugliese & Associates, 4408-B Reading Pike, Reading, PA 19605 | 4 | 12 |
Pugliese, Peter T | Pugliese & Associates, 4408-B Reading Pike, Reading, PA 19605 | 16 | 83 |
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