Multipartite high-affinity nucleic acid probes
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United States of America Patent
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Sep 17, 2002
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app pub date -
Jun 30, 2000
filing date -
Jun 30, 2000
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Abstract
The invention provides a collection of probes useful for hybridizing to a target nucleic acid. The probes associate with each other, binding with high affinity to the target nucleic acid, to form three-way junctions and other complexes. At least one of the probes in each collection includes a nucleic acid analog. Methods using the probes in hybridization and as primers are also provided.
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