Small molecules that elicit a polarized Th1 response and for modulation of cellular immunity
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United States of America Patent
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Sep 17, 2002
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N/A
app pub date -
Feb 24, 1999
filing date -
Feb 24, 1998
priority date (Note) -
Expired
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Abstract
The present invention relates to methods of using peptide-like compounds, e.g., aminocarboxylic acid amide derivatives, to bias the immune system toward producing, enhancing, or maintaining a polarized Th1 response, and to methods for treating diseases that improve by creating a Th1 response. The invention also relates to a method of treating diseases associated with elevated soluble TNF alpha levels by administering beta-alethine together with NAC to reduce soluble TNF alpha, and to a pharmaceutical composition comprising same. The present compounds can be used to modulate cytokines including IFN-gamma and IL-10.
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