Peptide nucleic acids
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United States of America Patent
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Sep 17, 2002
Grant Date -
N/A
app pub date -
Jul 15, 1994
filing date -
May 24, 1991
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Novel peptide nucleic acids and novel linked peptide nucleic acids, form triple stranded structures with nucleic acids. The peptide nucleic acids include ligands such as naturally occurring nucleobases attached to a peptide backbone through a suitable linker. Other nucleobases including C-pyrimidines and iso-pyrimidines can be used as the ligands in Hoogsteen strands to increase binding affinity. Two peptide nucleic acid strands are joined together with a linker to form a bis-peptide nucleic acid. The individual strands of the peptide nucleic acids in the bis compounds can be orientated either parallel or antiparallel to each other.
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