Dengue nucleic acid vaccines that induce neutralizing antibodies
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United States of America Patent
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Sep 24, 2002
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app pub date -
Jun 4, 1997
filing date -
Jun 4, 1996
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Abstract
A vaccine for promoting an immune response in a mammalian subject includes a eucaryotic plasmid expression vector which include at least part of the envelope gene and optionally, the PreM gene of dengue virus. In order to minimize immune enhancement, vaccines of up to the four serotypes of dengue are combined in a single vaccine. The vaccine in a suitable pharmaceutical carrier constitutes a pharmaceutical composition which is injected into the subject.
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