Method of detecting ultrasound contrast agent in soft tissue, and quantitating blood perfusion through regions of tissue
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United States of America Patent
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Oct 8, 2002
Grant Date -
Dec 27, 2001
app pub date -
Jan 19, 2001
filing date -
Jan 19, 2000
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A method for detection of ultrasound contrast agent in soft tissue according to the present invention includes utilizing an ultrasound transmit beam former and transducer array assembly for transmitting directive, focussed ultrasound pressure pulses with steerable transmit amplitude, transmit aperture, transmit focus, and transmit direction, and with temporal frequency components within a limited band B centered at a frequency f.sub.0, towards a region of soft tissue that contains ultrasound contrast agent bubbles. The transmit pulse parameters are arranged, preferably using multiple transmit pulses, so that the incident pressure pulse that is utilized for imaging of the contrast agent for a particular depth, has minimal variation over the actual image range. The non-linearly distorted, back-scattered ultrasound signal is received from both the tissue and the ultrasound contrast agent bubbles with the same ultrasound transducer assembly and the received array element signals are passed through a receiver beamformer that has a steerable spatially directive receiver sensitivity.
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