US Patent No: 6,461,641

Number of patents in Portfolio can not be more than 2000

Tumor delivery vehicles

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ATTORNEY / AGENT: (SPONSORED)

Importance

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Abstract

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The major problem with current direct delivery techniques of therapeutic reagents into solid tumors, especially of cells or large volumes of recombinant DNA reagents or drugs, has been resistance of the tissues to the influx of the fluid and/or cells, resulting in low quantities of the fluid and/or cells penetrating into and remaining in the tumor tissue to be treated. Increased penetration and/or reduced backflow and diversion through the point of entry, so that more material is introduced into and remains in the tumor, is obtained through the use of a viscous vehicle, most preferably having a similar density to tissue, for the material to be delivered. Preferred materials include solutions or suspensions of a polymeric material which gel or solidify at the time of or shortly after injection or implantation. In the preferred embodiment, the solution is injected via a catheter into regions of the tumor to be treated.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
FBP CORPORATIONSAN FRANCISCO, CA2

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Fick, James R Martinez, GA 4 30

Cited Art Landscape

Patent Info (Count) # Cites Year
 
NEUROTECH USA, INC. (2)
5,656,481 Compositions and methods for the delivery of biologically active molecules using cells contained in biocompatible capsules 38 1995
6,027,721 Device and method for encapsulated gene therapy 8 1996
 
WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (2)
4,868,116 Introduction and expression of foreign genetic material in epithelial cells 190 1986
4,980,286 In vivo introduction and expression of foreign genetic material in epithelial cells 279 1989
 
ADVANCED RESEARCH AND TECHNOLOGY INSTITUTE, INC. (1)
5,552,309 Use of polyols for improving the introduction of genetic material into cells 41 1994
 
ALLERGAN, INC. (1)
5,441,732 Reversible gelation emulsion compositions and methods of use 29 1992
 
COLD SPRING HARBOR LABORATORY (1)
5,674,703 Episomal vector systems and related methods 40 1993
 
FBP Corporation (1)
5,945,100 Tumor delivery vehicles 23 1996
 
HIMMELSTEIN, KENNETH J. (1)
5,599,534 Reversible gel-forming composition for sustained delivery of bio-affecting substances, and method of use 28 1994
 
MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE, INC. (1)
6,096,303 Method to enhance treatment of cystic tumors 5 1997
 
PHARMACEUTICAL DISCOVERY CORPORATION (1)
6,071,497 Microparticles for lung delivery comprising diketopiperazine 100 1997
 
REPLIGEN CORPORATION (1)
4,352,883 Encapsulation of biological material 441 1979
 
STEWARD RESEARCH AND SPECIALTY PROJECTS CORPORATION (1)
5,652,225 Methods and products for nucleic acid delivery 74 1996
 
THE REGENTS OF THE UNIVERSITY OF MICHIGAN (1)
5,763,416 Gene transfer into bone cells and tissues 96 1994
 
YALE UNIVERSITY (1)
6,090,784 RNA polymerase II peptides and methods of use 3 1995

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
Fundacao de Amparo a Pesquisa do Estado de Sao Paulo—FAPESP (1)
8,278,265 Methods, kits and compositions comprising crotamine 0 2007
 
TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (1)
8,391,959 Composition for improving efficiency of drug delivery 0 2005

Maintenance Fees

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11.5 Year Payment $7400.00 $3700.00 $1850.00 Apr 8, 2014
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Surcharge - 11.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge after expiration - Late payment is unavoidable $700.00 $350.00 $175.00
Surcharge after expiration - Late payment is unintentional $1,640.00 $820.00 $410.00