US Patent No: 6,461,641

Number of patents in Portfolio can not be more than 2000

Tumor delivery vehicles

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The major problem with current direct delivery techniques of therapeutic reagents into solid tumors, especially of cells or large volumes of recombinant DNA reagents or drugs, has been resistance of the tissues to the influx of the fluid and/or cells, resulting in low quantities of the fluid and/or cells penetrating into and remaining in the tumor tissue to be treated. Increased penetration and/or reduced backflow and diversion through the point of entry, so that more material is introduced into and remains in the tumor, is obtained through the use of a viscous vehicle, most preferably having a similar density to tissue, for the material to be delivered. Preferred materials include solutions or suspensions of a polymeric material which gel or solidify at the time of or shortly after injection or implantation. In the preferred embodiment, the solution is injected via a catheter into regions of the tumor to be treated.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
FBP CORPORATIONSAN FRANCISCO, CA0

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Fick, James R Martinez, GA 4 45

Cited Art Landscape

Patent Info (Count) # Cites Year
 
FBP Corporation (1)
* 5,945,100 Tumor delivery vehicles 37 1996
 
THE REGENTS OF THE UNIVERSITY OF MICHIGAN (1)
* 5,763,416 Gene transfer into bone cells and tissues 112 1994
 
YALE UNIVERSITY (1)
* 6,090,784 RNA polymerase II peptides and methods of use 4 1995
 
HIMMELSTEIN, KENNETH J. (1)
5,599,534 Reversible gel-forming composition for sustained delivery of bio-affecting substances, and method of use 35 1994
 
Cold Spring Harbor Laboratory (1)
* 5,674,703 Episomal vector systems and related methods 43 1993
 
ADVANCED RESEARCH & TECHNOLOGY INSTITUTE (1)
5,552,309 Use of polyols for improving the introduction of genetic material into cells 43 1994
 
MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE, INC. (1)
* 6,096,303 Method to enhance treatment of cystic tumors 6 1997
 
ALLERGAN, INC. (1)
5,441,732 Reversible gelation emulsion compositions and methods of use 32 1992
 
STEWARD RESEARCH AND SPECIALTY PROJECTS CORPORATION (1)
5,652,225 Methods and products for nucleic acid delivery 75 1996
 
PHARMACEUTICAL DISCOVERY CORPORATION (1)
* 6,071,497 Microparticles for lung delivery comprising diketopiperazine 132 1997
 
Whitehead Institute for Biomedical Research (2)
4,868,116 Introduction and expression of foreign genetic material in epithelial cells 212 1986
4,980,286 In vivo introduction and expression of foreign genetic material in epithelial cells 351 1989
 
NEUROTECH USA, INC. (2)
5,656,481 Compositions and methods for the delivery of biologically active molecules using cells contained in biocompatible capsules 43 1995
* 6,027,721 Device and method for encapsulated gene therapy 12 1996
* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
DUKE UNIVERSITY (1)
* 2011/0189,262 Methods and Compositions for Reducing Systemic Toxicity of Vectors 0 2006
 
Tel HaShomer Medical research Infrastructure and Service Ltd (1)
* 2009/0208,422 Composition for improving efficiency of drug delivery 2 2005
 
TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (2)
* 8,391,959 Composition for improving efficiency of drug delivery 0 2005
* 2011/0098,554 Monitoring of convection enhanced drug delivery 0 2005
 
INSTITUTO BUTANTAN (2)
8,278,265 Methods, kits and compositions comprising crotamine 0 2007
* 2008/0181,849 Methods, kits and compositions comprising crotamine 0 2007
* Cited By Examiner