Compounds, processes and intermediates for synthesis of mixed backbone oligomeric compounds
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United States of America Patent
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Oct 8, 2002
Grant Date -
Aug 23, 2001
app pub date -
Nov 29, 2000
filing date -
Feb 12, 1999
priority date (Note) -
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Abstract
Synthetic processes are provided wherein mixed backbone oligomeric compounds are prepared having at least one phosphodiester internucleoside linkage in addition to one or more phosphorothioate, phosphoramidate and boranophosphate internucleoside linkages. Novel H-phosphonate intermediates are also disclosed that are useful in the synthetic processes. The synthetic processes use a novel oxidation step to oxidize H-phosphonate internucleoside linkages to phosphodiester internucleoside linkages without degradation of adjacent phosphorothioate, phosphoramidate and boranophosphate internucleoside linkages. Also provided are synthetic intermediates useful in such processes.
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