Importance

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Abstract

The present invention provides a process for producing crystals of a polymorphic compound in a first crystal structure by introduction of the compound in a second crystal structure into a saturated brine solution of the compound under conditions in which formation of the first crystal structure is favored and without evaporation or changes in temperature. As the second crystal structure dissolves, the brine becomes supersaturated resulting in relief of supersaturation by formation of crystals of the first crystal structure. The process includes controlling supersaturation and its relief to achieve growth of existing crystals of the first crystal structure rather than nucleation and formation of new crystals. The resulting crystals are separated from insoluble impurities on a size separation basis.

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First Claim