Vaccination and methods against multiple sclerosis resulting from pathogenic responses by specific T cell populations
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United States of America Patent
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Oct 15, 2002
Issued Date -
N/A
app pub date -
Apr 29, 1993
filing date -
Mar 21, 1989
priority date (Note) -
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Abstract
The present invention provides vaccines and a means of vaccinating a mammal so as to prevent or control specific T cell mediated pathologies or to treat the unregulated replication of T cells. The vaccine is composed of a T cell receptor (TCR) or a fragment thereof corresponding to a TCR present on the surface of T cells mediating the pathology. The vaccine fragment can be a peptide corresponding to sequences of TCRs characteristic of the T cells mediating said pathology. The vaccine is administered to the mammal in a manner that induces an immunologically effective response so as to affect the course of the disease. The invention additionally provides specific .beta.-chain variable regions of the T cell receptor, designated V.beta.6.2/3, V.beta.6.5, V.beta.2, V.beta.5.1, V.beta.13 and V.beta.7, which are central to the pathogenesis of multiple sclerosis (MS).
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