Process for the synthesis of oligomeric compounds

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United States of America Patent

PATENT NO 6465628
SERIAL NO

09288679

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Abstract

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Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.

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Patent Owner(s)

Patent OwnerAddress
IONIS PHARMACEUTICALS INC2855 GAZELLE COURT CARLSBAD CA 90210

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Capaldi, Daniel C San Diego, CA 25 390
Cole, Douglas L San Diego, CA 192 1362
Guzaev, Andrei Carlsbad, CA 12 124
Krotz, Achim San Diego, CA 11 395
Manoharan, Muthiah Carlsbad, CA 491 18658
Ravikumar, Vasulinga T Carlsbad, CA 39 625

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