High specificity homocysteinases
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United States of America Patent
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Oct 22, 2002
Issued Date -
N/A
app pub date -
Apr 12, 2000
filing date -
Jul 24, 1997
priority date (Note) -
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Abstract
Homocysteinase enzymes are disclosed which have sufficient specificity for homocysteine, as compared to cysteine that hydrogen sulfide can be used as a measure of homocysteine in a biological fluid even in the presence of substantial amounts of cysteine, exceeding the level of homocysteine. The enzyme of desired specificity can be readily prepared by mutation and screening of naturally occurring homocysteinases or by constructing chimeric forms.
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