US Patent No: 6,469,035

Number of patents in Portfolio can not be more than 2000

Methods of pretreating hyperlipidemic individuals with a flush inhibiting agent prior to the start of single daily dose nicotinic acid therapy to reduce flushing provoked by nicotinic acid

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Abstract

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The present invention relates to pretreating individuals with an effective amount of a flush inhibiting agent for a sufficient period of time prior to the start of single daily dose nicotinic acid therapy to reduce the capacity of nicotinic acid to induce flushing reactions in such individuals during nicotinic acid therapy. In accordance with the present invention, the flush inhibiting agents are administered orally one to four times a day, and preferably one to two times per day, for between about 7 to about 14 days prior to the start of the nicotinic acid therapy. Examples of flush inhibiting agents include nonsteroidal anti-inflammatory agents. Aspirin is a preferred flush inhibiting agent and may be orally administered in daily doses of between about 80 mg to about 1000 mg, and preferably between about 80 mg and about 650 mg, and more preferably between about 80 mg and about 325 mg, during the pretreatment period. Also consistent with the present invention, the pretreatment therapy may be continued during and administered concurrently with the nicotinic acid therapy, in which the nicotinic acid is preferably administered once per day as a single dose during the evening hours or before or at bedtime. The nicotinic acid may be administered alone or in combination with HMG-CoA reductase inhibitors as well as other lipid-altering agents, like cholestyramine and colestipol.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
KOS LIFE SCIENCES LLCABBOTT PARK, IL5

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cefali, Eugenio A Fort Lauderdale, FL 15 88

Cited Art Landscape

Patent Info (Count) # Cites Year
 
NATIONAL BIOSOURCE, INC. (2)
4,911,917 Cholesterol-lowering combination comopsitions of magnesium salt and niacin 13 1988
4,965,252 Cholesterol-lowering combination compositions of guar gum and niacin 19 1988
 
TCF BANK SAVINGS FSB N/K/A TCF NATIONAL BANK (2)
5,126,145 Controlled release tablet containing water soluble medicament 105 1990
5,268,181 Method of using niacin to control nocturnal cholesterol synthesis 19 1992

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
CORTRIA CORPORATION (2)
8,211,922 1-methylnicotinamide derivatives and formulations for treatment of lipoprotein abnormalities 0 2010
8,481,570 1-methylnicotinaide derivatives and formulations of treatment of lipoprotein abnormalities 0 2012
 
PHARMENA SPOLKA AKCYJNA (PHARMENA S.A.) (2)
7,935,717 Method for treating hypertriglyceridemia, dyslipidemia and hypercholesterolemia with a 1-methylnicotinamide salt 0 2005
8,124,631 Use of quaternary pyridinium salts as vasoprotective agents 0 2010
 
VITALIS LLC (2)
8,404,275 Combination tablet with chewable outer layer 0 2009
8,652,520 Combination tablet with chewable outer layer 0 2012
 
ARCHIMEDES DEVELOPMENT LIMITED (1)
8,460,702 Pharmaceutical compositions 0 2006
 
KOS LIFE SCIENCES, INC. (1)
7,998,506 Nicotinic acid compositions for treating hyperlipidemia and related methods therefor 0 2003
 
REDDY US THERAPEUTICS, INC. (1)
8,008,328 Methods for the treatment of diabetes-associated dyslipdemia 0 2007
 
SOLVOTRIN THERAPEUTICS LTD. (1)
8,834,858 Treatment for dyslipidemia 0 2011

Maintenance Fees

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11.5 Year Payment $7400.00 $3700.00 $1850.00 Apr 22, 2014
Fee Large entity fee small entity fee micro entity fee
Surcharge - 11.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge after expiration - Late payment is unavoidable $700.00 $350.00 $175.00
Surcharge after expiration - Late payment is unintentional $1,640.00 $820.00 $410.00