US Patent No: 6,471,994
Number of patents in Portfolio can not be more than 2000
Pharmaceutical excipient having improved compressibility
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Oct 29, 2002
Issued date -
Aug 27, 1999
filing date -
09/384,130
serial no -
In Force
status
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Abstract
A microcrystalline cellulose-based excipient having improved compressibility, whether utilized in direct compression, dry granulation or wet granulation formulations, is disclosed. The excipient is an agglomerate of microcrystalline cellulose particles and from about 0.1% to about 20% silicon dioxide particles, by weight of microcrystalline cellulose, wherein the microcrystalline cellulose and silicon dioxide are in intimate association with each other. The silicon dioxide utilized in the novel excipient has a particle size from about 1 nanometer to about 100 microns. Most preferably, the silicon dioxide is a grade of colloidal silicon dioxide. An extra low moisture excipient is provided which exhibits improved compressibility as compared to conventional microcrystalline cellulose, while providing a moisture content of from about 0.5 to 2.5% LOD, preferably between about 0.5 and about 1.8%, more preferably between 0.8 and 1.5%, and most preferably between about 0.8 and about 1.2 %.
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First Claim
Related Publications
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International Classification(s)
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Cited Art
| Patent Info | (Count) | # Cites | Year |
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| 4,744,987 Coprocessed microcrystalline cellulose and calcium carbonate composition and its preparation | 84 | 1987 | |
| 5,075,115 Process for polymerizing poly(lactic acid) | 81 | 1990 | |
| 5,192,569 Fat-like bulking agent for aqueous foods comprising microcrystalline cellulose and a galactomannan gum | 66 | 1991 | |
| 5,441,753 Coprocessed particulate bulking and formulating AIDS: their composition, production, and use | 38 | 1994 | |
| 5,462,761 Microcrystalline cellulose and glucomannan aggregates | 31 | 1994 | |
| 5,505,982 Chocolate confection | 61 | 1995 | |
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| 5,019,397 Aqueous emulsion for pharmaceutical dosage form | 60 | 1988 | |
| 4,946,685 Cellulosic dosage form | 57 | 1988 | |
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| 4,533,674 Process for preparing a sugar and starch free spray-dried vitamin C powder containing 90 percent ascorbic acid | 35 | 1983 | |
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| 4,536,511 Medicaments containing muzolimine, their use and processes for their production | 11 | 1984 | |
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| 4,664,915 Compressed and formed alkaline component suitable for use in buffered aspirin product | 38 | 1986 | |
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| 4,849,227 Pharmaceutical compositions | 100 | 1987 | |
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| 5,733,578 Directly compressible high load acetaminophen formulations | 22 | 1995 | |
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| 5,462,747 Pharmaceutical sustained release matrix | 63 | 1995 | |
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| 5,560,926 Process for the production of an S-ibuprofen-containing tablet | 21 | 1994 | |
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| 4,232,052 Process for powdering high fat foodstuffs | 36 | 1979 | |
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| 5,030,400 Process and an apparatus for agglomeration of a powdery material | 57 | 1990 | |
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| 5,478,574 Agglomerated hydrophilic complexes with multi-phasic release characteristics | 27 | 1993 | |
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| 5,858,409 Hydrolyzed cellulose granulations for pharmaceuticals | 35 | 1996 | |
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| 5,441,731 Compounds | 12 | 1992 | |
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| 4,923,981 Use of parenchymal cell cellulose to improve comestibles | 40 | 1989 | |
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| 5,447,729 Multilamellar drug delivery systems | 42 | 1994 | |
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| 5,126,145 Controlled release tablet containing water soluble medicament | 97 | 1990 | |
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| 5,322,698 Process for the preparation of a tablet or dragee composition containing a heat-, light- and moisture-sensitive active ingredient having monoclinic crystal structure | 25 | 1992 | |
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| 4,810,516 Reduced calorie and reduced fat chocolate confectionery compositions | 61 | 1987 | |
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| 4,303,846 Sintered electrode in a discharge tube | 24 | 1980 | |
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| 4,910,023 Drug in combination with flavor masking agent and method for making same | 32 | 1988 | |
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| 4,721,709 Novel pharmaceutical compositions containing hydrophobic practically water-insoluble drugs adsorbed on pharmaceutical excipients as carrier; process for their preparation and the use of said compositions | 47 | 1984 | |
Patent Citation Ranking
Maintenance Fees
| Fee | Large entity fee | small entity fee | micro entity fee | due date |
|---|---|---|---|---|
| 11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Apr 29, 2014 |
| Fee | Large entity fee | small entity fee | micro entity fee |
|---|---|---|---|
| Surcharge - 11.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
| Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
| Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |