US Patent No: 6,471,994

Number of patents in Portfolio can not be more than 2000

Pharmaceutical excipient having improved compressibility

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Abstract

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A microcrystalline cellulose-based excipient having improved compressibility, whether utilized in direct compression, dry granulation or wet granulation formulations, is disclosed. The excipient is an agglomerate of microcrystalline cellulose particles and from about 0.1% to about 20% silicon dioxide particles, by weight of microcrystalline cellulose, wherein the microcrystalline cellulose and silicon dioxide are in intimate association with each other. The silicon dioxide utilized in the novel excipient has a particle size from about 1 nanometer to about 100 microns. Most preferably, the silicon dioxide is a grade of colloidal silicon dioxide. An extra low moisture excipient is provided which exhibits improved compressibility as compared to conventional microcrystalline cellulose, while providing a moisture content of from about 0.5 to 2.5% LOD, preferably between about 0.5 and about 1.8%, more preferably between 0.8 and 1.5%, and most preferably between about 0.8 and about 1.2 %.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
J. RETTENMAIER & SOEHNE GMBH + CO. KGROSENBERG13

International Classification(s)

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  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hunter, Edward A Cadosia, NY 32 790
Sherwood, Bob E Amenia, NY 35 852
Staniforth, John N Bath, GB 39 1316

Cited Art Landscape

Patent Info (Count) # Cites Year
 
R.P. SCHERER TECHNOLOGIES, INC. (1)
5,858,409 Hydrolyzed cellulose granulations for pharmaceuticals 42 1996
 
Supernus Pharmaceuticals, Inc. (1)
5,447,729 Multilamellar drug delivery systems 47 1994
 
Other [Check patent profile for assignment information] (1)
4,721,709 Novel pharmaceutical compositions containing hydrophobic practically water-insoluble drugs adsorbed on pharmaceutical excipients as carrier; process for their preparation and the use of said compositions 57 1984
 
BASF CORPORATION (1)
4,533,674 Process for preparing a sugar and starch free spray-dried vitamin C powder containing 90 percent ascorbic acid 35 1983
 
TOSHIBA CORPORATION (1)
4,303,846 Sintered electrode in a discharge tube 24 1980
 
ALZA CORPORATION (2)
5,019,397 Aqueous emulsion for pharmaceutical dosage form 102 1988
4,946,685 Cellulosic dosage form 59 1988
 
BRISTOL-MYERS SQUIBB COMPANY (1)
4,664,915 Compressed and formed alkaline component suitable for use in buffered aspirin product 62 1986
 
SPB INC., 62% INTEREST (1)
4,923,981 Use of parenchymal cell cellulose to improve comestibles 47 1989
 
PENWEST PHARMACEUTICALS CO. (1)
* 5,478,574 Agglomerated hydrophilic complexes with multi-phasic release characteristics 28 1993
 
TEVA GYOGYSZERGYAR RESZVENYTARSASAG (1)
5,322,698 Process for the preparation of a tablet or dragee composition containing a heat-, light- and moisture-sensitive active ingredient having monoclinic crystal structure 25 1992
 
NIRO HOLDING A/S (1)
5,030,400 Process and an apparatus for agglomeration of a powdery material 79 1990
 
The Procter & Gamble Company (1)
4,810,516 Reduced calorie and reduced fat chocolate confectionery compositions 64 1987
 
Warner-Lambert Company (1)
* 4,910,023 Drug in combination with flavor masking agent and method for making same 32 1988
 
Smith Kline & French Laboratories Limited (1)
5,441,731 Compounds 12 1992
 
Bayer Aktiengesellschaft (1)
4,536,511 Medicaments containing muzolimine, their use and processes for their production 11 1984
 
FMC CORPORATION (6)
4,744,987 Coprocessed microcrystalline cellulose and calcium carbonate composition and its preparation 114 1987
5,075,115 Process for polymerizing poly(lactic acid) 120 1990
5,192,569 Fat-like bulking agent for aqueous foods comprising microcrystalline cellulose and a galactomannan gum 71 1991
5,441,753 Coprocessed particulate bulking and formulating AIDS: their composition, production, and use 44 1994
5,462,761 Microcrystalline cellulose and glucomannan aggregates 32 1994
5,505,982 Chocolate confection 71 1995
 
J. RETTENMAIER & SOEHNE GMBH + CO. KG (1)
5,733,578 Directly compressible high load acetaminophen formulations 26 1995
 
MCNEIL-PPC, INC. (1)
5,462,747 Pharmaceutical sustained release matrix 77 1995
 
MERCK PATENT GMBH (1)
5,560,926 Process for the production of an S-ibuprofen-containing tablet 23 1994
 
Eurasiam Laboratories, Inc. (1)
4,849,227 Pharmaceutical compositions 156 1987
 
TCF NATIONAL BANK (1)
5,126,145 Controlled release tablet containing water soluble medicament 125 1990
* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (1)
* 2004/0005,357 Extended-release tablets comprising divalproex sodium 4 2002
 
JRS Pharma (1)
* 2010/0285,164 Orally Disintegrating Excipient 3 2009
 
PROCOM ONE, INC. (5)
8,513,299 Methods of using low-dose doxepin for the improvement of sleep 0 2007
* 2007/0281,990 Methods of using low-dose doxepin for the improvement of sleep 4 2007
9,498,462 Doxepin trans isomers and isomeric mixtures and methods of using the same to treat sleep disorders 0 2012
9,463,181 Doxepin isomers and isomeric mixtures and methods of using the same to treat sleep disorders 0 2012
9,486,437 Methods of using low-dose doxepin for the improvement of sleep 0 2015
 
OMJ IRELAND LTD. (2)
* 2003/0219,484 Immediate release dosage form comprising shell having openings therein 6 2003
* 2004/0253,312 Immediate release dosage form comprising shell having openings therein 16 2004
 
FREESLATE, INC. (1)
* 2004/0219,602 Evaluating effects of exposure conditions on drug samples over time 1 2004
 
ISP INVESTMENTS INC. (1)
* 2016/0120,989 COPROCESSED SILICA COATED POLYMER COMPOSITION 0 2014
 
JOHNSON & JOHNSON CONSUMER INC. (6)
7,879,354 Rapidly disintegrating gelatinous coated tablets 3 2004
* 2005/0152,970 Rapidly disintegrating gelatinous coated tablets 8 2004
8,067,029 Rapidly disintegrating gelatinous coated tablets 0 2004
8,815,290 Rapidly disintegrating gelatinous coated tablets 0 2010
* 2011/0086,098 RAPIDLY DISINTEGRATING GELATINOUS COATED TABLETS 0 2010
9,149,438 Rapidly disintegrating gelatinous coated tablets 0 2014
 
FOREST LABORATORIES, INC. (2)
* 2004/0186,122 Method of treating acute pain with a unitary dosage form comprising ibuprofin and oxycodone 2 2003
* 2005/0059,690 Method of treating acute pain with a unitary dosage form comprising ibuprofen and oxycodone 0 2004
 
Metrics, Inc. (1)
* 2004/0091,544 Coated dibasic calcium phosphate 1 2003
 
PERNIX SLEEP, INC. (1)
9,107,898 Methods of using low-dose doxepin for the improvement of sleep 0 2012
 
AVANTOR PERFORMANCE MATERIALS, LLC (1)
* 2010/0055,180 Directly Compressible Granular Microcrystalline Cellulose Based Excipient, Manufacturing Process and Use Thereof 1 2009
 
EVONIK DEGUSSA GMBH (1)
* 2006/0292,192 Pharmaceutical and cosmetic formulations 35 2003
 
SOMAXON PHARMACEUTICALS, INC. (4)
* 2008/0182,890 METHODS OF USING LOW-DOSE DOXEPIN FOR THE IMPROVEMENT OF SLEEP 5 2007
* 2010/0105,614 ULTRA LOW DOSE DOXEPIN AND METHODS OF USING THE SAME TO TREAT SLEEP DISORDERS 5 2007
* 2009/0074,862 LOW-DOSE DOXEPIN FORMULATIONS AND METHODS OF MAKING AND USING THE SAME 4 2008
* 2011/0166,215 METHODS OF IMPROVING THE PHARMACOKINETICS OF DOXEPIN 5 2011
 
AVANTOR PERFORMANCE MATERIALS, INC. (1)
* 2011/0092,598 Driectly Compressible High Functionality Granular Microcrystalline Cellulose Based Excipient, Manufacturing Process and Use Thereof 0 2008
 
J. RETTENMAIER & SOEHNE GMBH + CO. KG (7)
6,866,867 Process for preparing a directly compressible solid dosage form containing microcrystalline cellulose 10 2001
* 2002/0182,259 Process for preparing a directly compressible solid dosage form containing microcrystalline cellulose 0 2001
* 7,179,488 Process for co-spray drying liquid herbal extracts with dry silicified MCC 6 2002
* 2003/0203,050 Process for co-spray drying liquid herbal extracts with dry silicified MCC 1 2002
* 6,746,693 Pharmaceutical excipient having improved compressibility 5 2002
* 6,858,231 Pharmaceutical excipient having improved compressibility 7 2003
* 2005/0196,439 Process for co-spray drying agents with dry silicified MCC 5 2004
* Cited By Examiner