US Patent No: 6,471,994

Number of patents in Portfolio can not be more than 2000

Pharmaceutical excipient having improved compressibility

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Abstract

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A microcrystalline cellulose-based excipient having improved compressibility, whether utilized in direct compression, dry granulation or wet granulation formulations, is disclosed. The excipient is an agglomerate of microcrystalline cellulose particles and from about 0.1% to about 20% silicon dioxide particles, by weight of microcrystalline cellulose, wherein the microcrystalline cellulose and silicon dioxide are in intimate association with each other. The silicon dioxide utilized in the novel excipient has a particle size from about 1 nanometer to about 100 microns. Most preferably, the silicon dioxide is a grade of colloidal silicon dioxide. An extra low moisture excipient is provided which exhibits improved compressibility as compared to conventional microcrystalline cellulose, while providing a moisture content of from about 0.5 to 2.5% LOD, preferably between about 0.5 and about 1.8%, more preferably between 0.8 and 1.5%, and most preferably between about 0.8 and about 1.2 %.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
J. RETTENMAIER & SOEHNE GMBH + CO. KGROSENBERG30

International Classification(s)

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  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hunter, Edward A San Diego, CA 43 514
Sherwood, Bob E Amenia, NY 43 559
Staniforth, John N Bath, GB 45 1062

Cited Art Landscape

Patent Info (Count) # Cites Year
 
FMC CORPORATION (6)
4,744,987 Coprocessed microcrystalline cellulose and calcium carbonate composition and its preparation 101 1987
5,075,115 Process for polymerizing poly(lactic acid) 96 1990
5,192,569 Fat-like bulking agent for aqueous foods comprising microcrystalline cellulose and a galactomannan gum 68 1991
5,441,753 Coprocessed particulate bulking and formulating AIDS: their composition, production, and use 41 1994
5,462,761 Microcrystalline cellulose and glucomannan aggregates 31 1994
5,505,982 Chocolate confection 65 1995
 
ALZA CORPORATION (2)
5,019,397 Aqueous emulsion for pharmaceutical dosage form 69 1988
4,946,685 Cellulosic dosage form 58 1988
 
BASF CORPORATION (1)
4,533,674 Process for preparing a sugar and starch free spray-dried vitamin C powder containing 90 percent ascorbic acid 35 1983
 
Bayer Aktiengesellschaft (1)
4,536,511 Medicaments containing muzolimine, their use and processes for their production 11 1984
 
BRISTOL-MYERS SQUIBB COMPANY (1)
4,664,915 Compressed and formed alkaline component suitable for use in buffered aspirin product 53 1986
 
Eurasiam Laboratories, Inc. (1)
4,849,227 Pharmaceutical compositions 115 1987
 
J. RETTENMAIER & SOEHNE GMBH + CO. KG (1)
5,733,578 Directly compressible high load acetaminophen formulations 23 1995
 
MCNEIL-PPC, INC. (1)
5,462,747 Pharmaceutical sustained release matrix 72 1995
 
MERCK PATENT GMBH (1)
5,560,926 Process for the production of an S-ibuprofen-containing tablet 21 1994
 
National Starch and Chemical Corporation (1)
4,232,052 Process for powdering high fat foodstuffs 36 1979
 
NIRO HOLDING A/S (1)
5,030,400 Process and an apparatus for agglomeration of a powdery material 62 1990
 
PENWEST PHARMACEUTICALS CO. (1)
5,478,574 Agglomerated hydrophilic complexes with multi-phasic release characteristics 28 1993
 
R.P. SCHERER TECHNOLOGIES, INC. (1)
5,858,409 Hydrolyzed cellulose granulations for pharmaceuticals 38 1996
 
Smith Kline & French Laboratories Limited (1)
5,441,731 Compounds 12 1992
 
SPB INC., 62% INTEREST (1)
4,923,981 Use of parenchymal cell cellulose to improve comestibles 42 1989
 
Supernus Pharmaceuticals, Inc. (1)
5,447,729 Multilamellar drug delivery systems 43 1994
 
TCF BANK SAVINGS FSB N/K/A TCF NATIONAL BANK (1)
5,126,145 Controlled release tablet containing water soluble medicament 105 1990
 
TEVA GYOGYSZERGYAR RESZVENYTARSASAG (1)
5,322,698 Process for the preparation of a tablet or dragee composition containing a heat-, light- and moisture-sensitive active ingredient having monoclinic crystal structure 25 1992
 
The Procter & Gamble Company (1)
4,810,516 Reduced calorie and reduced fat chocolate confectionery compositions 64 1987
 
TOSHIBA CORPORATION (1)
4,303,846 Sintered electrode in a discharge tube 24 1980
 
Warner-Lambert Company (1)
4,910,023 Drug in combination with flavor masking agent and method for making same 32 1988
 
Other [Check patent profile for assignment information] (1)
4,721,709 Novel pharmaceutical compositions containing hydrophobic practically water-insoluble drugs adsorbed on pharmaceutical excipients as carrier; process for their preparation and the use of said compositions 52 1984

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
J. RETTENMAIER & SOEHNE GMBH + CO. KG (4)
6,866,867 Process for preparing a directly compressible solid dosage form containing microcrystalline cellulose 6 2001
7,179,488 Process for co-spray drying liquid herbal extracts with dry silicified MCC 2 2002
6,746,693 Pharmaceutical excipient having improved compressibility 1 2002
6,858,231 Pharmaceutical excipient having improved compressibility 1 2003
 
MCNEIL-PPC, INC. (3)
7,879,354 Rapidly disintegrating gelatinous coated tablets 1 2004
8,067,029 Rapidly disintegrating gelatinous coated tablets 0 2004
8,815,290 Rapidly disintegrating gelatinous coated tablets 0 2010
 
PROCOM ONE, INC. (1)
8,513,299 Methods of using low-dose doxepin for the improvement of sleep 0 2007

Maintenance Fees

Fee Large entity fee small entity fee micro entity fee due date
11.5 Year Payment $7400.00 $3700.00 $1850.00 Apr 29, 2014
Fee Large entity fee small entity fee micro entity fee
Surcharge - 11.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge after expiration - Late payment is unavoidable $700.00 $350.00 $175.00
Surcharge after expiration - Late payment is unintentional $1,640.00 $820.00 $410.00