Compounds and methods for modulating OB-cadherin mediated cell adhesion
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United States of America Patent
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Oct 29, 2002
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N/A
app pub date -
May 5, 1998
filing date -
May 5, 1998
priority date (Note) -
Expired
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Abstract
Modulating agents for inhibiting or enhancing OB-cadherin mediated cell adhesion are provided. The modulating agents comprise one or more of: (a) an OB-cadherin CAR sequence; (b) a peptide analogue or peptidomimetic thereof; (c) an antibody or antigen-binding fragment thereof that specifically binds an OB-cadherin CAR sequence; and/or (d) a polynucleotide encoding any of the foregoing peptide sequences. Methods for using such modulating agents for modulating OB-cadherin-mediated cell adhesion in a variety of contexts are also provided.
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