Suppression of malignancy utilizing ribonucleotide reductase R1
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United States of America Patent
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Oct 29, 2002
Grant Date -
Jan 10, 2002
app pub date -
Sep 24, 1998
filing date -
Mar 19, 1997
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Abstract
The present invention provides a method of modulating the malignant properties of a cell in a human or other mammal by contacting a neoplastic cell with a growth modulating amount of an expressible nucleic acid sequence for ribonucleotide reductase R1 of the mammal. The present invention also provides and uses a growth modulating amount of the ribonucleotide reductase R1 protein or biologically active peptide to modulate the malignant properties of a cell in a human or other mammal. The method provides for a generally elevated expression of the R1 component of mammalian ribonucleotide reductase. The expressible nucleic acid sequence can be in the form of a vector for gene therapy.
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