Importance

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Abstract

Oligomers are prepared substantially free of error sequences by sequentially adding monomers to a growing chain bound to a support through a first selectably cleavable linkage, a first capture moiety and a second selectably cleavable linkage. At the completion of monomer addition, the completed oligomer is cleaved from the support to reveal the first capture moiety and purified by virtue of the presence of a second capture moiety, e.g., a terminal blocking group, and the first capture moiety. A support-bound oligomer having the structural formula (I) S--[X1].sub.n1 --SC1--CP2--[X2].sub.n2 --SC3--T.sup.1 --X--T.sup.2 --SC2--CP1 (I) is also provided wherein T.sup.1, T.sup.2, X1, X2, n1, n2, SC1, SC2, SC3, CP1 and CP2 are as defined herein.

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First Claim