Importance

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Abstract

The invention comprises a wide range of pierceable and memory-recloseable septa cover for multi-well plates for PCR or other small sample well processes, where such seals are joined into an easily applied or removed sheet or otherwise joined means. A reaction chamber well comprises a liquid level portion at the bottom that contains the various levels of reaction liquid, a super-liquid portion comprising the gas volumes above the reaction liquid. In one form of the invention embodiments, the cover comprises a gas tight seal between the cover and the side of the well substantially above the liquid level, thereby forming the super-liquid space. The disturbance, pressure change and/or gas exchange in this small gas space results in a rather dramatic potential change in reaction or mixing results. The invention cover reduces each of these to a minimum not attainable in the prior art.

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First Claim