US Patent No: 6,480,743

Number of patents in Portfolio can not be more than 2000

System and method for adaptive brain stimulation

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Abstract

An implantable neurostimulator adapted to provide adaptive electrical brain stimulation includes a detection subsystem for isolating an electrographic signal characteristic and a stimulation system for applying an adaptive stimulation signal based at least in part upon the electrographic signal characteristic and correlated with the electrographic signal. Undesired learning of and acclimation to stimulation characteristics are avoided and stimulation efficacy is improved by adapting or otherwise varying the adaptive stimulation signal in relation to the electrographic signal.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
NEUROPACE, INC.MOUNTAIN VIEW, CA84

International Classification(s)

  • [Classification Symbol]
  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kirkpatrick, Bruce Santa Clara, CA 13 347
Pless, Benjamin D Atherton, CA 117 3688

Cited Art

Patent Info (Count) # Cites Year
 
CIT GROUP/BUSINESS CREDIT, INC. (1)
5,025,807 Neurocybernetic prosthesis 243 1989
 
NEUROPACE, INC. (1)
6,016,449 System for treatment of neurological disorders 361 1997

Patent Citation Ranking

Forward Cites

Patent Info (Count) # Cites Year
 
MEDTRONIC, INC. (88)
7,894,908 Neurostimulation therapy optimization based on a rated session log 0 2003
7,548,786 Library for management of neurostimulation therapy programs 25 2003
7,505,815 Neurostimulation therapy usage diagnostics 24 2003
7,489,970 Management of neurostimulation therapy using parameter sets 26 2003
7,463,928 Identifying combinations of electrodes for neurostimulation therapy 11 2003
8,187,181 Scoring of sensed neurological signals for use with a medical device system 0 2003
7,715,919 Control of treatment therapy during start-up and during operation of a medical device system 3 2003
7,282,030 Timed delay for redelivery of treatment therapy for a medical device system 12 2003
7,280,867 Clustering of recorded patient neurological activity to determine length of a neurological event 12 2003
7,242,983 Channel-selective blanking for a medical device system 70 2003
7,149,572 Phase shifting of neurological signals in a medical device system 13 2003
7,146,211 Signal quality monitoring and control for a medical device system 27 2003
7,079,977 Synchronization and calibration of clocks for a medical device and calibrated clock 33 2003
7,991,479 Neurostimulator programmer with clothing attachable antenna 0 2003
7,729,766 Circuit board construction for handheld programmer 6 2003
7,561,921 Neurostimulator programmer with internal antenna 5 2003
7,356,369 Z-axis assembly of medical device programmer 4 2003
7,272,445 Medical device programmer with faceplate 10 2003
7,263,406 Medical device programmer with selective disablement of display during telemetry 6 2003
7,203,549 Medical device programmer with internal antenna and display 50 2003
7,181,286 Distributed system for neurostimulation therapy programming 15 2003
8,397,732 Implantation of low-profile implantable medical device 0 2003
7,848,817 Coupling module of a modular implantable medical device 2 2003
7,529,586 Concavity of an implantable medical device 3 2003
7,392,089 Reducing relative intermodule motion in a modular implantable medical device 3 2003
7,242,982 Overmold for a modular implantable medical device 25 2003
7,212,864 Modular implantable medical device 11 2003
7,617,002 Selection of neurostimulator parameter configurations using decision trees 13 2004
7,252,090 Selection of neurostimulator parameter configurations using neural network 13 2004
7,239,926 Selection of neurostimulator parameter configurations using genetic algorithms 8 2004
7,184,837 Selection of neurostimulator parameter configurations using bayesian networks 17 2004
7,826,901 Generation of therapy programs and program groups 1 2004
7,596,399 Implantation of implantable medical device 3 2004
7,317,947 Headset recharger for cranially implantable medical devices 8 2004
7,263,401 Implantable medical device with a nonhermetic battery 22 2004
7,596,408 Implantable medical device with anti-infection agent 6 2004
7,758,568 Implantable therapeutic substance delivery device 3 2004
8,041,418 System and method for regulating cardiac triggered therapy to the brain 0 2005
8,041,419 System and method for monitoring or treating nervous system disorders 0 2005
7,949,391 System and method for regulating cardiac triggered therapy to the brain 0 2005
7,949,392 System and method for monitoring or treating nervous system disorders 0 2005
7,945,316 System and method for monitoring or treating nervous system disorders 0 2005
7,865,244 System and method for regulating cardiopulmonary triggered therapy to the brain 0 2005
7,787,944 System and method for regulating cardiac triggered therapy to the brain 0 2005
7,684,855 System and method for regulating cardiac triggered therapy to the brain 0 2005
7,680,539 System and method for regulating cardiopulmonary triggered therapy to the brain 0 2005
7,624,293 Synchronization and calibration of clocks for a medical device and calibrated clock 0 2006
7,321,837 Synchronization and calibration of clocks for a medical device and calibrated clock 10 2006
7,819,909 Therapy programming guidance based on stored programming history 0 2006
7,774,067 Autogeneration of neurostimulation therapy program groups 1 2006
8,108,038 System and method for segmenting a cardiac signal based on brain activity 2 2006
8,380,300 Efficacy visualization 0 2006
8,326,431 Implantable medical device for the concurrent treatment of a plurality of neurological disorders and method therefore 0 2006
8,306,624 Patient-individualized efficacy rating 0 2006
7,715,920 Tree-based electrical stimulator programming 1 2006
7,976,465 Phase shifting of neurological signals in a medical device system 1 2006
7,917,206 Signal quality monitoring and control for a medical device system 2 2006
8,190,251 Method and apparatus for the treatment of movement disorders 1 2006
8,165,683 Method and apparatus for detection of nervous system disorders 0 2006
7,764,989 Method and apparatus for detection of nervous system disorders 3 2006
7,761,145 Method and apparatus for detection of nervous system disorders 3 2006
7,761,146 Method and apparatus for detection of nervous system disorders 4 2006
8,068,915 Generation of therapy programs and program groups 0 2007
7,933,656 Distributed system for neurostimulation therapy programming 1 2007
7,979,130 Method and apparatus for detection of nervous system disorders 0 2007
8,095,220 Neurostimulation therapy usage diagnostics 0 2007
8,214,035 System and method for utilizing brain state information to modulate cardiac therapy 0 2007
8,209,009 System and method for segmenting a cardiac signal based on brain stimulation 0 2007
8,209,019 System and method for utilizing brain state information to modulate cardiac therapy 1 2007
8,112,153 System and method for monitoring or treating nervous system disorders 0 2007
8,068,911 System and method for regulating cardiopulmonary triggered therapy to the brain 0 2007
8,000,788 Implantable medical device for treating neurological conditions including ECG sensing 0 2007
7,801,619 Tree-based electrical stimulator programming for pain therapy 1 2007
7,706,889 Tree-based electrical stimulator programming 0 2007
8,112,148 System and method for monitoring cardiac signal activity in patients with nervous system disorders 0 2007
8,108,046 System and method for using cardiac events to trigger therapy for treating nervous system disorders 0 2007
7,853,323 Selection of neurostimulator parameter configurations using neural networks 0 2007
7,881,796 Implantable medical device with a nonhermetic battery 2 2007
7,933,646 Clustering of recorded patient neurological activity to determine length of a neurological event 0 2007
7,631,415 Method for assembling a programmer for a medical device 2 2008
8,155,749 Management of neurostimulation therapy using parameter sets 1 2008
8,086,313 Implantable medical device with anti-infection agent 0 2009
8,280,478 Evaluation of implantation site for implantation of implantable medical device 0 2009
8,233,990 Selection of neurostimulator parameter configurations using decision trees 0 2009
8,068,903 Method and apparatus for detection of nervous system disorders 0 2010
8,311,636 Tree-based electrical stimulator programming 0 2010
8,352,039 Programming therapy delivered by implantable medical device 0 2011
8,214,051 Distributed system for neurostimulation therapy programming 0 2011
 
CYBERONICS, INC. (36)
7,209,787 Apparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease 73 2003
7,242,984 Apparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease 33 2004
7,277,758 Methods and systems for predicting future symptomatology in a patient suffering from a neurological or psychiatric disorder 40 2004
7,324,851 Closed-loop feedback-driven neuromodulation 36 2004
7,231,254 Closed-loop feedback-driven neuromodulation 79 2004
7,366,571 Neurostimulator with activation based on changes in body temperature 11 2004
7,561,918 Autocapture in a neurostimulator 3 2005
7,454,245 Trained and adaptive response in a neurostimulator 6 2005
7,403,820 Closed-loop feedback-driven neuromodulation 37 2005
7,499,752 Selective nerve stimulation for the treatment of eating disorders 2 2005
7,747,325 Systems and methods for monitoring a patient's neurological disease state 3 2005
7,489,561 Implantable medical device with reconfigurable non-volatile program 1 2005
7,620,455 Cranial nerve stimulation to treat eating disorders 8 2005
8,428,731 Sequenced therapy protocols for an implantable medical device 0 2005
7,957,796 Using physiological sensor data with an implantable medical device 0 2005
7,555,344 Selective neurostimulation for treating epilepsy 0 2005
7,643,881 Neurostimulation with activation based on changes in body temperature 0 2006
7,996,079 Input response override for an implantable medical device 0 2006
7,974,697 Medical imaging feedback for an implantable medical device 0 2006
7,801,601 Controlling neuromodulation using stimulus modalities 6 2006
7,962,220 Compensation reduction in tissue stimulation therapy 2 2006
7,869,885 Threshold optimization for tissue stimulation therapy 2 2006
7,869,867 Implantable neurostimulator with refractory stimulation 0 2006
7,853,329 Monitoring efficacy of neural modulation therapy 7 2006
7,904,175 Trans-esophageal vagus nerve stimulation 2 2007
7,869,884 Non-surgical device and methods for trans-esophageal vagus nerve stimulation 0 2007
7,974,701 Dosing limitation for an implantable medical device 2 2007
7,930,035 Providing output indicative of subject's disease state 2 2007
7,623,928 Controlling a subject's susceptibility to a seizure 1 2007
7,676,263 Minimally invasive system for selecting patient-specific therapy parameters 7 2007
7,962,214 Non-surgical device and methods for trans-esophageal vagus nerve stimulation 1 2007
8,260,426 Method, apparatus and system for bipolar charge utilization during stimulation by an implantable medical device 0 2008
8,036,736 Implantable systems and methods for identifying a contra-ictal condition in a subject 4 2008
8,204,603 Blocking exogenous action potentials by an implantable medical device 0 2008
8,239,028 Use of cardiac parameters in methods and systems for treating a chronic medical condition 0 2009
8,306,627 Dosing limitation for an implantable medical device 0 2011
 
ADVANCED NEUROMODULATION SYSTEMS, INC. (33)
7,305,268 Systems and methods for automatically optimizing stimulus parameters and electrode configurations for neuro-stimulators 14 2001
7,146,217 Methods and apparatus for effectuating a change in a neural-function of a patient 29 2002
7,221,981 Electrode geometries for efficient neural stimulation 13 2002
7,756,584 Methods and apparatus for effectuating a lasting change in a neural-function of a patient 0 2002
7,831,305 Neural stimulation system and method responsive to collateral neural activity 3 2002
7,236,830 Systems and methods for enhancing or optimizing neural stimulation therapy for treating symptoms of Parkinson's disease and/or other movement disorders 22 2002
7,024,247 Systems and methods for reducing the likelihood of inducing collateral neural activity during neural stimulation threshold test procedures 34 2003
7,236,831 Methods and apparatus for effectuating a lasting change in a neural-function of a patient 19 2003
7,302,298 Methods and systems employing intracranial electrodes for neurostimulation and/or electroencephalography 10 2003
7,672,730 Methods and apparatus for effectuating a lasting change in a neural-function of a patient 0 2003
6,959,215 Methods for treating essential tremor 55 2003
7,565,199 Methods for treating and/or collecting information regarding neurological disorders, including language disorders 0 2003
7,299,096 System and method for treating Parkinson's Disease and other movement disorders 7 2003
7,353,064 Systems and methods for enhancing or optimizing neural stimulation therapy for treating symptoms of movement disorders and/or other neurologic dysfunction 7 2004
6,990,377 Systems and methods for facilitating and/or effectuating development, rehabilitation, restoration, and/or recovery of visual function through neural stimulation 46 2004
7,684,866 Apparatus and methods for applying neural stimulation to a patient 6 2004
7,565,200 Systems and methods for selecting stimulation sites and applying treatment, including treatment of symptoms of Parkinson's disease, other movement disorders, and/or drug side effects 0 2004
7,483,747 Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy 8 2005
7,856,264 Systems and methods for patient interactive neural stimulation and/or chemical substance delivery 2 2005
7,577,481 Methods and apparatus for effectuating a lasting change in a neural-function of a patient 0 2006
7,620,456 Systems and methods for reducing the likelihood of inducing collateral neural activity during neural stimulation threshold test procedures 4 2006
7,917,225 Systems and methods for selecting stimulation sites and applying treatment, including treatment of symptoms of parkinson's disease, other movement disorders, and/or drug side effects 0 2006
7,908,009 Systems and methods for selecting stimulation sites and applying treatment, including treatment of symptoms of Parkinson's disease, other movement disorders, and/or drug side effects 0 2006
7,742,820 Systems and methods for selecting stimulation sites and applying treatment, including treatment of symptoms of parkinson's disease, other movement disorders, and/or drug side effects 0 2006
7,437,196 Systems and methods for selecting stimulation sites and applying treatment, including treatment of symptoms of Parkinson's disease, other movement disorders, and/or drug side effects 4 2006
7,729,773 Neural stimulation and optical monitoring systems and methods 0 2006
8,126,568 Electrode geometries for efficient neural stimulation 0 2007
8,065,012 Methods and apparatus for effectuating a lasting change in a neural-function of a patient 1 2007
7,983,762 Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy 0 2008
8,073,546 Methods and apparatus for effectuating a lasting change in a neural-function of a patient 0 2010
8,195,300 Systems and methods for automatically optimizing stimulus parameters and electrode configurations for neuro-stimulators 1 2011
8,433,414 Systems and methods for reducing the likelihood of inducing collateral neural activity during neural stimulation threshold test procedures 0 2012
8,412,335 Systems and methods for automatically optimizing stimulus parameters and electrode configurations for neuro-stimulators 0 2012
 
BRAINSGATE LTD. (15)
7,120,489 Method and apparatus for stimulating the sphenopalatine ganglion to modify properties of the BBB and cerebral blood flow 10 2001
7,146,209 Stimulation for treating eye pathologies 5 2002
7,636,597 Surgical tools and techniques for stimulation 1 2003
7,190,998 Method and apparatus for stimulating the sphenopalatine ganglion to modify properties of the BBB and cerbral blood flow 5 2004
7,117,033 Stimulation for acute conditions 5 2004
7,640,062 Methods and systems for management of alzheimer's disease 1 2005
7,561,919 SPG stimulation via the greater palatine canal 2 2006
7,729,759 Method and apparatus for stimulating the sphenopalatine ganglion to modify properties of the BBB and cerebral blood flow 1 2006
8,055,347 Stimulation for treating brain events and other conditions 1 2006
7,684,859 Stimulation of the OTIC ganglion for treating medical conditions 1 2007
7,860,569 Long-term SPG stimulation therapy for prevention of vascular dementia 1 2007
8,010,189 SPG stimulation for treating complications of subarachnoid hemorrhage 0 2007
7,908,000 Transmucosal electrical stimulation 0 2007
8,229,571 Greater palatine canal stylet 0 2009
8,406,869 Post-acute electrical stimulation treatment of adverse cerebrovascular events 0 2011
 
NEURONETICS, INC. (14)
7,153,256 Reducing discomfort caused by electrical stimulation 10 2003
7,614,996 Reducing discomfort caused by electrical stimulation 0 2003
7,651,459 Method and apparatus for coil positioning for TMS studies 1 2004
7,320,664 Reducing discomfort caused by electrical stimulation 6 2004
8,177,702 Method and apparatus for determining the proximity of a TMS coil to a subject's head 0 2004
7,601,115 Seizure therapy method and apparatus 0 2004
8,088,058 Articulating arm 0 2005
7,396,326 Ferrofluidic cooling and acoustical noise reduction in magnetic stimulators 5 2005
7,824,324 Magnetic core for medical procedures 0 2005
7,963,903 Magnetic core for medical procedures 0 2005
8,118,722 Reducing discomfort caused by electrical stimulation 0 2005
7,560,058 Magnetic core for medical procedures 2 2006
8,128,549 Capacitor failure detection 0 2007
8,246,529 Magnetic core for medical procedures 0 2010
 
NEUROPACE, INC. (12)
7,174,213 Electrical stimulation strategies to reduce the incidence of seizures 12 2001
7,177,674 Patient-specific parameter selection for neurological event detection 35 2002
7,813,793 Seizure sensing and detection using an implantable device 0 2004
8,073,544 Neurostimulator involving stimulation strategies and process for using it 0 2005
7,894,905 Implantable system enabling responsive therapy for pain 0 2006
7,966,073 Differential neurostimulation therapy driven by physiological therapy 2 2006
8,131,352 System and method for automatically adjusting detection thresholds in a feedback-controlled neurological event detector 0 2007
7,801,618 Auto adjusting system for brain tissue stimulator 2 2007
8,412,333 Neurostimulator involving stimulation strategies and process for using it 0 2011
8,326,417 Neurostimulator involving stimulation strategies and process for using it 0 2011
8,224,452 Differential neurostimulation therapy driven by physiological therapy 0 2011
8,423,145 Differential neurostimulation therapy driven by physiological therapy 0 2012
 
BOSTON SCIENTIFIC SCIMED, INC. (9)
8,060,207 Method of intravascularly delivering stimulation leads into direct contact with tissue 0 2003
7,295,875 Method of stimulating/sensing brain with combination of intravascularly and non-vascularly delivered leads 3 2004
7,590,454 Modular stimulation lead network 5 2004
7,177,702 Collapsible/expandable electrode leads 22 2004
7,231,260 Intravascular self-anchoring electrode body with arcuate springs, spring loops, or arms 23 2004
7,286,879 Method of stimulating fastigium nucleus to treat neurological disorders 5 2004
7,937,160 Methods for delivering cortical electrode leads into patient's head 1 2004
7,818,063 Method of intravascularly delivering stimulation leads into brain to stimulate the SPG 4 2007
8,103,350 Method of stimulation fastigium nucleus to treat neurological disorders 1 2007
 
PALO ALTO INVESTORS (6)
7,149,574 Treatment of conditions through electrical modulation of the autonomic nervous system 42 2003
7,676,269 Treatment of female fertility conditions through modulation of the autonomic nervous system 8 2003
7,899,527 Treatment of conditions through modulation of the autonomic nervous system during at least one predetermined menstrual cycle phase 0 2004
7,363,076 Treatment of conditions through modulation of the autonomic nervous system 26 2004
7,738,952 Treatment of conditions through modulation of the autonomic nervous system 6 2005
8,121,690 Treatment of female fertility conditions through modulation of the autonomic nervous system 0 2010
 
BOSTON SCIENTIFIC NEUROMODULATION CORPORATION (5)
7,003,352 Treatment of epilepsy by brain stimulation 36 2003
8,019,441 Collapsible/expandable tubular electrode leads 0 2006
8,425,534 Cam lock burr hole plug for securing stimulation lead 0 2008
8,043,304 Cam lock burr hole plug for securing retainer/plug base 1 2008
8,185,208 Modular stimulation lead network 0 2009
 
CYBERKINETICS NEUROTECHNOLOGY SYSTEMS, INC. (5)
7,991,461 Patient training routine for biological interface system 0 2005
8,095,209 Biological interface system with gated control signal 0 2005
7,901,368 Neurally controlled patient ambulation system 1 2005
8,060,194 Biological interface system with automated configuration 0 2005
7,881,780 Biological interface system with thresholded configuration 2 2005
 
FLINT HILLS SCIENTIFIC, L.L.C. (5)
6,934,580 Stimulation methodologies and apparatus for control of brain states 91 2003
7,551,956 Stimulation methodologies and apparatus for control of brain states 2 2005
8,417,344 Dynamic cranial nerve stimulation based on brain state determination from cardiac data 0 2008
8,337,404 Detecting, quantifying, and/or classifying seizures using multimodal data 0 2010
8,382,667 Detecting, quantifying, and/or classifying seizures using multimodal data 0 2011
 
CATHOLIC HEALTHCARE WEST (3)
8,219,188 Synchronization of vagus nerve stimulation with the cardiac cycle of a patient 0 2007
8,150,508 Vagus nerve stimulation method 0 2007
8,280,505 Vagus nerve stimulation method 0 2009
 
DUKE UNIVERSITY (3)
7,209,788 Closed loop brain machine interface 18 2001
6,993,392 Miniaturized high-density multichannel electrode array for long-term neuronal recordings 16 2002
7,983,756 Miniaturized high-density multichannel electrode array for long-term neuronal recordings 1 2005
 
FORSCHUNGSZENTRUM JULICH GMBH (3)
7,974,698 Method and apparatus for desynchronization of neural brain activity 1 2006
8,000,796 Method and device for decoupling and/or desynchronizing neural brain activity 0 2006
8,116,874 Method and device for desynchronizing neural brain activity, controller and method for treating neural and/or psychiatric disorders 0 2007
 
BRAINGATE CO., LLC (2)
7,751,877 Neural interface system with embedded id 4 2004
7,647,097 Transcutaneous implant 6 2004
 
BROWN UNIVERSITY RESEARCH FOUNDATION (2)
7,280,870 Optically-connected implants and related systems and methods of use 7 2003
7,392,079 Neurological signal decoding 10 2006
 
GEORGE MASON UNIVERSITY (2)
6,665,562 Adaptive electric field modulation of neural systems 77 2000
6,873,872 Adaptive electric field modulation of neural systems 48 2002
 
PACESETTER, INC. (2)
6,961,617 Method and apparatus to backup, update and share data among implantable cardiac stimulation device programmers 21 2001
7,529,588 Method and apparatus to backup, update and share data among implantable cardiac stimulation device programmers 1 2005
 
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (2)
8,398,692 System for optical stimulation of target cells 0 2008
8,401,609 System, method and applications involving identification of biological circuits such as neurological characteristics 0 2008
 
BIO NEURONICS CORPORATION (1)
8,295,934 Systems and methods of reducing artifact in neurological stimulation systems 0 2006
 
BRAIN STATE TECHNOLOGIES, LLC (1)
8,249,699 Method of affecting balanced brain function with relational ambient sound 0 2009
 
CARDIAC PACEMAKERS, INC. (1)
8,103,341 System for abating neural stimulation side effects 0 2006
 
CEREPHEX CORPORATION (1)
8,280,502 Method and apparatus for utilizing amplitude-modulated pulse-width modulation signals for neurostimulation and treatment of neurological disorders using electrical stimulation 0 2010
 
FONDAZIONE IRCCS "CA' GRANDA - OSPEDALE MAGGIORE POLICLINICO" (1)
8,078,281 Apparatus for treating neurological disorders by means of chronic adaptive brain stimulation as a function of local biopotentials 0 2006
 
FUNCTIONAL NEUROSCIENCE INC. (1)
8,000,794 Method and apparatus for affecting neurologic function and/or treating Neurologic dysfunction through timed neural stimulation 6 2004
 
GREAT LAKES BIO SCIENCES, LLC. (1)
7,715,910 Method and apparatus for utilizing amplitude-modulated pulse-width modulation signals for neurostimulation and treatment of neurological disorders using electrical stimulation 0 2006
 
MASSACHUSETTS INSTITUTE OF TECHNOLOGY (1)
7,212,851 Microstructured arrays for cortex interaction and related methods of manufacture and use 19 2002
 
NEURO AND CARDIAC TECHNOLOGIES, LLC (1)
7,076,307 Method and system for modulating the vagus nerve (10th cranial nerve) with electrical pulses using implanted and external components, to provide therapy neurological and neuropsychiatric disorders 47 2004
 
NEW YORK UNIVERSITY (1)
8,315,686 Cortical electrode array and method for stimulating and recording brain activity 0 2009
 
NUERONETICS, INC. (1)
7,857,746 System and method to reduce discomfort using nerve stimulation 1 2004
 
TRUSTEES OF DARTMOUTH COLLEGE (1)
8,433,415 Apparatus and method for modulating neurochemical levels in the brain 0 2012

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