Prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
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United States of America Patent
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Nov 19, 2002
Grant Date -
Mar 28, 2002
app pub date -
May 24, 2001
filing date -
May 24, 2000
priority date (Note) -
Expired
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Abstract
The present invention is directed to prodrugs of certain 3-(pyrrol-2-yl-methylidene)-2-indolinone derivatives that modulate the activity of protein kinases ('PKs'). Pharmaceutical compositions comprising these compounds, methods of treating diseases related to abnormal PK activity utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.
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