N-oxides of heterocyclic esters, amides, thioesters, and ketones
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United States of America Patent
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Nov 26, 2002
Grant Date -
Nov 1, 2001
app pub date -
Apr 26, 2001
filing date -
Feb 28, 1997
priority date (Note) -
Expired
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Abstract
This invention relates to neurotrophic low molecular weight, small molecule N-oxides of heterocyclic esters amides, thioesters, and ketones having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or rotamase, enzyme activity.
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