iso-CBI and iso-CI analogs of CC-1065 duocarmycins
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United States of America Patent
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Nov 26, 2002
Grant Date -
Apr 25, 2002
app pub date -
Jul 17, 2001
filing date -
Oct 14, 1997
priority date (Note) -
Expired
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Abstract
A series of bioactive analogs of (+)-CC-1065 (1) and the duocarmycins 2 and 3 are synthesized. The bioactive analogs include either iso-CI or iso-CBI (6 and 7) as a DNA alkylation subunit. Conjugated to the DNA alkylating subunits are a variety of DNA binding subunits. The bioactive analogs maintain their DNA selectivity and display enhance reactivity.
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