Neurotherapeutic use of carboxypeptidase inhibitors
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United States of America Patent
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Dec 3, 2002
Grant Date -
Mar 7, 2002
app pub date -
Feb 14, 2001
filing date -
Aug 16, 1999
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Abstract
Administration of inhibitors of carboxypeptidase E provides significant neurotropic effects in warm-blooded vertebrates evidenced inter alia by anxiolytic and anti-aggressive behavior and enhanced cognition. Certain .beta.-Lactam antibiotics, most significantly, certain 1-oxa-1-dethia cephems with blood brain barrier transport, exhibit potent therapeutic neurologic activity.
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