US Patent No: 6,491,039

Number of patents in Portfolio can not be more than 2000

Medical procedure

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Abstract

The use of an intravascular cooling element to induce hypothermia in connection with a medical procedure. According to a first aspect of the present, invention, a coronary bypass procedure is conducted in which a patient's blood is oxygenated with the patient's lungs and in which blood is circulated using the patient's heart or using an intracorporeal pump. The procedure preferably comprises: (a) positioning a heat transfer element in a blood vessel of a patient; (b) cooling the body of the patient to less than 35.degree. C., more preferably 32.+-..degree. C., using the heat transfer element; and (c) forming a fluid communicating graft between an arterial blood supply and the coronary artery. The body of the patient is preferably heated to about 37.degree. C. using the heat transfer element subsequent to the step of forming the fluid communicating graft. According to a further aspect of the invention, a hypothermic medical procedure is provided while a patient is in a conscious or semiconscious state, comprising (a) administering a beta-blocking drug to the patient; (b) delivering a heat transfer element to a blood vessel of the patient; and (c) cooling a region of the patient or the body of the patient to less than 35.degree. C. using the heat transfer element.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
INNERCOOL THERAPIES, INC., A DELAWARE CORPORATIONSAN DIEGO, CA110

International Classification(s)

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  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dobak, III John D La Jolla, CA 86 3309

Cited Art

Patent Info (Count) # Cites Year
 
INNERCOOL THERAPIES, INC., A DELAWARE CORPORATION (18)
6,051,019 Selective organ hypothermia method and apparatus 141 1998
6,042,559 Insulated catheter for selective organ perfusion 161 1998
5,957,963 Selective organ hypothermia method and apparatus 190 1998
6,231,595 Circulating fluid hypothermia method and apparatus 107 1998
6,096,068 Selective organ cooling catheter and method of using the same 158 1998
6,251,129 Method for low temperature thrombolysis and low temperature thrombolytic agent with selective organ temperature control 103 1998
6,254,626 Articulation device for selective organ cooling apparatus 100 1998
6,238,428 Selective organ cooling apparatus and method employing turbulence-inducing element with curved terminations 93 1999
6,312,452 Selective organ cooling catheter with guidewire apparatus and temperature-monitoring device 99 1999
6,224,624 Selective organ cooling apparatus and method 113 1999
6,149,677 Circulating fluid hypothermia method 147 1999
6,235,048 Selective organ hypothermia method and apparatus 102 1999
6,325,818 Inflatable cooling apparatus for selective organ hypothermia 68 1999
2001/0001,830 Method and device for applications of selective organ cooling 67 2001
2001/0029,394 Selective organ cooling catheter with guidewire apparatus and temperature-monitoring device 68 2001
2001/0011,184 Method and apparatus for location and temperature specific drug action such as thrombolysis 63 2001
2001/0011,185 Articulation device for selective organ cooling apparatus 65 2001
2001/0041,923 Patient temperature regulation method and apparatus 76 2001
 
ZOLL CIRCULATION, INC. (17)
5,486,208 Method and apparatus for controlling a patient's body temperature by in situ blood temperature modification 224 1994
5,837,003 Method and apparatus for controlling a patient's body temperature by in situ blood temperature modification 213 1996
6,033,383 Temperature regulating catheter and methods 127 1996
5,879,329 Infusion systems and methods for introducing fluids into the body within a desired temperature range 181 1997
6,149,673 Method for controlling a patient's body temperature by in situ blood temperature modification 115 1998
6,149,676 Catheter system for controlling a patient's body temperature by in situ blood temperature modification 112 1998
6,306,161 Catheter system for controlling a patient's body temperature by in situ blood temperature modification 75 1998
5,989,238 Infusion systems and methods for introducing fluids into the body within a desired temperature range 165 1998
6,146,411 Cooling system for indwelling heat exchange catheter 153 1998
6,019,783 Cooling system for therapeutic catheter 159 1999
6,290,717 Temperature probe and interconnect cable for hypothermia catheter temperature feedback 95 1999
6,165,207 Method of selectively shaping hollow fibers of heat exchange catheter 87 1999
6,287,326 Catheter with coiled multi-lumen heat transfer extension 114 1999
6,231,594 Method of controlling body temperature while reducing shivering 142 1999
6,149,670 Method and system for treating cardiac arrest using hypothermia 129 1999
6,264,679 Heat exchange catheter with discrete heat exchange elements 107 1999
6,299,599 Dual balloon central venous line catheter temperature control system 111 1999
 
BOSTON SCIENTIFIC SCIMED, INC. (8)
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5,588,438 System and method for controlling the temperature of a catheter-mounted heater 102 1995
5,799,661 Devices and methods for port-access multivessel coronary artery bypass surgery 331 1995
5,807,318 Method of perfusing the coronary vasculature 65 1996
5,957,879 Methods and devices for maintaining cardiopulmonary bypass and arresting a patient's heart 60 1997
 
MEDTRONIC CRYOCATH LP (7)
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5,281,213 Catheter for ice mapping and ablation 470 1992
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5,899,899 Cryosurgical linear ablation structure 262 1997
6,241,718 Method for inhibiting restenosis 30 1998
 
VENTION MEDICAL ADVANCED COMPONENTS, INC. (7)
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5,624,392 Heat transfer catheters and methods of making and using same 324 1994
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5,902,268 Heat transfer catheter apparatus and method of making and using same 151 1995
 
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ORGAN RECOVERY SYSTEMS, INC. (5)
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5,827,222 Method of treating at least one of brain and associated nervous tissue injury 110 1995
 
CORDIS CORPORATION (3)
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4,748,979 Plaque resolving device 157 1987
5,807,391 Cryo-ablation catheter 159 1996
 
DEL MAR MEDICAL TECHNOLOGIES (3)
6,251,130 Device for applications of selective organ cooling 111 1998
6,261,312 Inflatable catheter for selective organ heating and cooling and method of using the same 109 1998
6,245,095 Method and apparatus for location and temperature specific drug action such as thrombolysis 106 1999
 
MEDTRONIC AVE, INC. (3)
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4,820,349 Dilatation catheter with collapsible outer diameter 303 1987
5,358,486 Multiple layer high strength balloon for dilatation catheter 169 1992
 
TERUMO CARDIOVASCULAR SYSTEMS CORPORATION (3)
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5,395,331 Retrograde coronary sinus catheter having a ribbed balloon 145 1993
 
THE TEXAS A&M UNIVERSITY SYSTEM (3)
5,190,539 Micro-heat-pipe catheter 177 1990
5,417,686 Temperature control mechanisms for a micro heat pipe catheter 133 1992
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UROLOGIX, INC. (3)
5,620,480 Method for treating benign prostatic hyperplasia with thermal therapy 138 1994
5,800,486 Device for transurethral thermal therapy with cooling balloon 105 1996
5,861,021 Microwave thermal therapy of cardiac tissue 175 1996
 
ARIZANT HEALTHCARE INC. (2)
5,733,318 Convertible thermal blanket 96 1996
5,800,480 Support apparatus with a plurality of thermal zones providing localized cooling 111 1996
 
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (2)
5,486,204 Method of treating a non-penetrating head wound with hypothermia 146 1994
5,906,636 Heat treatment of inflamed tissue 145 1997
 
BREG, INC. (2)
5,241,951 Therapeutic nonambient temperature fluid circulation system 84 1991
5,330,519 Therapeutic nonambient temperature fluid circulation system 90 1993
 
CORDIS WEBSTER, INC. (2)
5,462,521 Fluid cooled and perfused tip for a catheter 362 1993
5,643,197 Fluid cooled and perfused tip for a catheter 282 1994
 
ENDOCARE, INC. (2)
5,437,673 Closed circulation tissue warming apparatus and method of using the same in prostate surgery 164 1993
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IRVINE BIOMEDICAL, INC. (2)
5,913,856 Catheter system having a porous shaft and fluid irrigation capabilities 167 1998
6,290,697 Self-guiding catheter system for tissue ablation 92 1998
 
LIFE SCIENCE HOLDINGS, INC. (2)
5,913,885 Brain cooling device and method for cooling 134 1995
6,277,143 Brain cooling apparatus and method for cooling the brain 52 1999
 
MEDTRONIC, INC. (2)
6,015,378 Method and apparatus for temporarily immobilizing a local area tissue 213 1996
6,006,134 Method and device for electronically controlling the beating of a heart using venous electrical stimulation of nerve fibers 230 1998
 
MISONIX, INC. (2)
5,306,261 Catheter with collapsible wire guide 125 1993
5,443,456 Catheter with collapsible wire guide 92 1994
 
OLYMPUS OPTICAL CO., LTD. (2)
5,106,360 Thermotherapeutic apparatus 410 1991
5,433,740 Method and apparatus for thermotherapy 113 1993
 
PRUTECH RESEARCH AND DEVELOPMENT PARTNERSHIP (2)
5,191,883 Device for heating tissue in a patient's body 308 1990
5,368,591 Heated balloon catheters 191 1992
 
THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (2)
5,531,776 Non-invasive aortic impingement and core and cerebral temperature manipulation method 194 1994
5,716,386 Non-invasive aortic impingement and core and cerebral temperature manipulation 213 1996
 
UNIVERSITY OF PITTSBURGH (2)
5,383,854 Portable and modular cardiopulmonary bypass apparatus and associated aortic balloon catheter and associated method 152 1992
5,820,593 Portable and modular cardiopulmonar bypass apparatus and associated aortic balloon catheter and associated method 106 1996
 
AMERICAN CARDIAC ABLATION CO., INC. (1)
5,334,193 Fluid cooled ablation catheter 721 1992
 
AMS RESEARCH CORPORATION (1)
5,496,271 Combined hyperthermia and dilation catheter 260 1993
 
ANAND; RAJ K. (1)
4,860,744 Thermoelectrically controlled heat medical catheter 383 1987
 
ANRITSU CORPORATION (1)
4,969,740 Spectrometer 20 1989
 
ARTERIA MEDICAL SCIENCE, LLC (1)
5,250,070 Less traumatic angioplasty balloon for arterial dilatation 200 1991
 
BECTON, DICKINSON AND COMPANY (1)
5,545,708 Thermoplastic polyurethane method of making same and forming a medical article therefrom 33 1993
 
BERKLEY AND COMPANY, INC. (1)
4,484,586 Hollow conductive medical tubing 107 1982
 
BOSTON SCIENTIFIC CORPORATION (1)
4,762,129 Dilatation catheter 578 1986
 
BRADER, ERIC W. (1)
4,750,493 Method of preventing brain damage during cardiac arrest, CPR or severe shock 139 1986
 
CALIFORNIA AND ALSIUS CORPORATION (1)
6,126,684 Indwelling heat exchange catheter and method of using same 189 1998
 
CALIFORNIA AQUARIUM SUPPLY CO. (1)
5,365,750 Remote refrigerative probe 119 1992
 
CARDEON CORPORATION (1)
5,833,671 Triple lumen catheter with controllable antegrade and retrograde fluid flow 151 1996
 
CARDIAC CONCEPTS, INC. (1)
5,150,706 Cooling net for cardiac or transplant surgery 281 1991
 
CEDARS-SINAI MEDICAL CENTER (1)
5,196,024 Balloon catheter with cutting edge 295 1990
 
CINCINNATI SUB-ZERO PRODUCTS, INC. (1)
5,647,051 Cold therapy system with intermittent fluid pumping for temperature control 95 1995
 
COBE CARDIOVASCULAR, INC. (1)
5,269,749 Heat exchange device for inducing cardioplegia 105 1992
 
COMEDICUS INCORPORATED (1)
6,206,004 Treatment method via the pericardial space 100 1996
 
COOPERSURGICAL, INC. (1)
5,910,104 Cryosurgical probe with disposable sheath 74 1996
 
EMORY UNIVERSITY (1)
5,089,260 Method of treating ischemic tissue 87 1990
 
FOGARTY, THOMAS J. (1)
4,762,130 Catheter with corkscrew-like balloon 330 1987
 
FRESENIUS AG (1)
4,894,164 Apparatus for treating blood in an extracorporeal circuit 122 1987
 
FRIGITRONICS, INC., 770 RIVER ROAD, SHELTON, CONNECTICUT 06484, A DE. CORP. (1)
5,108,390 Flexible cryoprobe 251 1988
 
GYNECARE, INC. (1)
5,827,269 Heated balloon having a reciprocating fluid agitator 96 1996
 
HEMODYNAMICS TECHNOLOGY, INC. (1)
4,569,355 Method and apparatus for monitoring and diagnosing peripheral blood flow 98 1982
 
HFG HEALTHCO-4, LLC (1)
5,735,809 Fiber assembly for in vivo plasma separation 140 1996
 
HITACHI, LTD. (1)
4,502,286 Constant pressure type boiling cooling system 90 1983
 
INTERNATIONAL BUSINESS MACHINES CORPORATION (1)
5,310,440 Convection transfer system 112 1992
 
JAPAN CRESCENT, INC. (1)
5,578,008 Heated balloon catheter 125 1993
 
JOHNSON & JOHNSON INTERVENTIONAL SYSTEMS COMPANY (A DIVISION OF ETHICON, INC.) (1)
4,625,712 High-capacity intravascular blood pump utilizing percutaneous access 177 1983
 
JPMORGAN CHASE BANK, N.A. (1)
5,257,977 Technique for localized thermal treatment of mammals 195 1991
 
LABORATOIRES, P.O.S. (1)
4,766,151 Ethers and oxime ethers of alkylamino alcohols as medicaments and novel products, and processes for their preparation 8 1985
 
LAKE SHORE MEDICAL DEVELOPMENT PARTNERS, LTD. (1)
5,344,436 Localized heat transfer device 143 1992
 
LIFE RESUSCITATION TECHNOLOGIES (1)
5,584,804 Brain resuscitation and organ preservation device and method for performing the same 168 1995
 
MAQUET CARDIOVASCULAR LLC (1)
5,913,876 Method and apparatus for using vagus nerve stimulation in surgery 159 1997
 
MC MEDICAL DEVICES, INC. (1)
6,290,674 Method and apparatus for closing intracardiac septal defects 301 1999
 
MICROTEK MEDICAL, INC. (1)
5,800,483 System and method for sterile surgical-thermal drape with active air circulation 78 1996
 
MINOLTA CAMERA KABUSHIKI KAISHA (1)
5,231,595 Pyrometer 22 1991
 
PACESETTER, INC. (1)
5,824,030 Lead with inter-electrode spacing adjustment 161 1995
 
PEACOCK MYERS, P.C. (1)
5,916,242 Apparatus for rapid cooling of the brain and method of performing same 118 1997
 
PERCUSURGE, INC. (1)
6,022,336 Catheter system for emboli containment 256 1997
 
PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, UNIVERSITY OF, A NON-PROFIT PENNSYLVANIA CORPORATION (1)
5,879,316 Portable and modular cardiopulmonary bypass apparatus and associated aortic balloon catheter and associated method 120 1997
 
PITTSBURGH, UNIVERSITY OF, THE, COMMONWEALTH SYSTEM OF HIGHER EDUCATION, A NON-PROFIT PA CORP. (1)
5,906,588 Portable and modular cardiopulmonary bypass apparatus and associated aortic balloon and associated method 110 1997
 
PRUTECH RESEARCH AND DEVELOPMENT PARTNERSHIP II, A CALIFORNIA LIMITED PARTNERSHIP (1)
4,951,677 Acoustic imaging catheter and the like 302 1988
 
RESEARCH AGAINST CANCER, INC. (1)
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ROCKY MOUNTAIN RESEARCH, INC. (1)
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SPECIALIZED HEALTH PRODUCTS, INC. (1)
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SPEMBLY MEDICAL LIMITED (1)
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SURGERX MEDICAL, LLC (1)
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SYMBIOSIS CORPORATION (1)
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TARGET THERAPEUTICS, INC. (1)
4,655,746 Catheter device 265 1985
 
THE BETH ISRAEL HOSPITAL ASSOCIATION (1)
5,019,075 Method and apparatus for angioplasty 382 1990
 
THE CANCER RESEARCH INSTITUTE (1)
5,713,941 Apparatus for inducing whole body hyperthermia and method for treatment utilizing said whole body hyperthermia inducing apparatus 92 1993
 
THE GENERAL HOSPITAL CORPORATION (1)
4,817,624 Mini-bolus technique for thermodilution cardiac output measurements 69 1985
 
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (1)
6,024,740 Circumferential ablation device assembly 366 1997
 
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (1)
5,110,721 Method for hypothermic organ protection during organ retrieval 107 1989
 
THEMOCORPS,INC. (1)
6,110,168 Method and apparatus for controlling a patient's body temperature by in situ blood temperature modifications 120 1998
 
THERACARDIA, INC. (1)
6,200,280 Cardiac massage apparatus and method 18 1998
 
THOMAS JEFFERSON UNIVERSITY (1)
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TYCO HEALTHCARE GROUP LP (1)
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UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (1)
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UNIVERSITY OF MSSISSIPPI,THE, UNIVERSITY (1)
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VALLEYLAB INC. (1)
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WAYNE STATE UNIVERSITY (1)
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WITTELES, ELEONRA M., (1)
4,483,341 Therapeutic hypothermia instrument 125 1982
 
WRIGHT STATE UNIVERSITY (1)
5,269,369 Temperature regulation system for the human body using heat pipes 138 1991
 
OTHER [CHECK PATENT PROFILE FOR ASSIGNMENT INFORMATION] (23)
4,231,425 Extracorporeal circuit blood heat exchanger 97 1978
4,190,033 Closed flow caloric test method 89 1978
4,318,722 Infrared radiation cooler for producing physiologic conditions such as a comfort or hypothermia 84 1980
4,745,922 Cervical heat transfer and immobilization device 120 1986
4,920,963 Apparatus for preventing brain damage during cardiac arrest, CPR or severe shock 149 1988
4,904,237 Apparatus for the exchange of cerebrospinal fluid and a method of treating brain and spinal cord injuries 142 1988
5,018,521 Method of and apparatus for increased transfer of heat into or out of the body 98 1988
5,002,531 Dilation catheter with an inflatable balloon 173 1988
5,000,734 Probe intended to be introduced within a living body 157 1989
5,014,695 Kidney cooling jacket 108 1989
5,117,822 Silicone heart spoon 108 1991
5,211,631 Patient warming apparatus 186 1991
5,269,758 Intravascular catheter and method for treatment of hypothermia 197 1992
5,383,918 Hypothermia reducing body exclosure 124 1992
5,622,182 System for measuring core body temperature in vivo 78 1994
5,733,280 Cryogenic epicardial mapping and ablation 261 1995
5,871,526 Portable temperature control system 199 1996
5,913,886 Body temperature control system and method of temperature control 102 1996
5,954,741 Vena-cava filter 52 1996
5,888,241 Cannula pumps for temporary cardiac support and methods of their application and use 28 1997
2001/0014,799 Intravascular systems for corporeal cooling 5 2001
2001/0031,946 Catheter with multiple heating/cooling fibers employing fiber spreading features 56 2001
2001/0047,191 System for treating cardiac arrest 55 2001

Patent Citation Ranking

Forward Cites

Patent Info (Count) # Cites Year
 
ZOLL CIRCULATION, INC. (10)
8,128,595 Method for a central venous line catheter having a temperature control system 0 2001
6,572,640 Method and apparatus for cardiopulmonary bypass patient temperature control 17 2001
7,425,216 System and method for treating cardiac arrest and myocardial infarction 2 2005
7,181,927 Primary heat exchanger for patient temperature control 2 2005
7,951,182 System and method for leak detection in external cooling pad 0 2005
7,892,269 External heat exchange pad for patient 0 2006
7,822,485 Method and apparatus for spinal cooling 0 2006
7,867,266 Temperature management system with assist mode for use with heart-lung machine 0 2006
7,892,270 Temperature management system and method for burn patients 0 2006
8,353,893 System and method for rapidly cooling cardiac arrest patient 0 2007
 
VYTRONUS, INC. (4)
7,950,397 Method for ablating body tissue 1 2007
7,942,871 Device for ablating body tissue 1 2007
8,414,508 System and method for delivery of energy to tissue while compensating for collateral tissue 0 2009
8,146,603 Method for ablating body tissue 0 2011
 
BOSTON SCIENTIFIC SCIMED, INC. (1)
7,485,109 Targeted cooling of tissue within a body 0 2006

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