Ultrasound enhancement of transdermal transport
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United States of America Patent
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-
Dec 10, 2002
Grant Date -
Apr 18, 2002
app pub date -
May 21, 2001
filing date -
Jun 28, 1996
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Methods and devices for application of ultrasound to a small area of skin for enhancing transdermal transport. An ultrasound beam having a first focal diameter is channelled into a beam having a second, smaller diameter without substantial loss of energy. Higher energy ultrasound can be used while causing less pain. Alternatively, ultrasound energy is applied through a vibrating element positioned just contacting, above or extending into the skin. Use of the element facilitates extraction of analyte and may enhance drug delivery. A two step noninvasive method involves application of ultrasound to increase skin permeability and removal of ultrasound followed by transdermal transport that can be further enhanced using a physical enhancer.
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