Biphasic multicomponent pharmaceutical dosage forms containing substances able to modify the partitioning of drugs
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United States of America Patent
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Dec 17, 2002
Grant Date -
Mar 21, 2002
app pub date -
Oct 1, 1999
filing date -
May 13, 1997
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The invention provides a biphasic multicomponent pharmaceutical composition consisting of an oil phase and a water phase, comprising one or more lipophilic or oil carrier, one or more hydrophilic or aqueous carrier, one or more ionic or nonionic type surfactant, one or more cosurfactant, one or more active principle for pharmaceutical use, and a compound able to modify the partition of the active principle between said phases selected from the group consisting of N- methyl pyrrolidone (NMP), isopropyl alcohol, propylene glycol, ethoxy-di-glycol, .beta.-cyclodextrin, hydroxypropyl .beta.-cyclodextrin and dimethyl .beta.-cyclodextrin. The invention also provides a method for making the composition.
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