Method for enhanced protein stabilization and for production of cell lines useful for production of such stabilized proteins
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United States of America Patent
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Dec 17, 2002
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app pub date -
Apr 6, 2000
filing date -
May 28, 1999
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Abstract
A method for increasing production yield of viruses, viral proteins, and other related biological materials through enhanced control and stabilization of protein production via stress proteins and the resultant protein products. The present invention is also directed to methods for selection or engineering of cell lines yielding such enhanced stabilized products. More specifically, example embodiments of the present invention are directed to methods for enhancing production of a viral agent, production of cell lines exhibiting permanent genetic modification, production of permissive eucaryotic cell lines, enhancing functional recombinant product yield, and the products of such methods.
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