In vivo selection of primitive hematopoietic cells
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United States of America Patent
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Dec 31, 2002
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N/A
app pub date -
May 4, 1999
filing date -
Nov 4, 1996
priority date (Note) -
Expired
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Abstract
The invention is directed to a method of in vivo selection for genetically modified hematopoietic progenitor cells from nonmodified hematopoietic cells in a subject. Ibis goal is accomplished by introducing mutant dihydrofolate reductase genes into hematopoietic progenitor cells and then administering to a subject harboring the resultant transformed cells an antifolate and a nucleoside transport inhibitor. The invention is also directed to nucleic acids encoding mutant dihydrofolate reductase genes and to hematopoietic cells transformed with such mutant genes.
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