Metabolic controlled fermentation procedure for the manufacture of lovastatin hydroxy acid
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United States of America Patent
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Dec 31, 2002
Grant Date -
N/A
app pub date -
Apr 5, 2000
filing date -
Mar 20, 1998
priority date (Note) -
Expired
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Abstract
A method for producing mevinolin by a microorganism in a fermentation process having a seed culture stage and a main fermentation stage, including a) cultivating a microorganism biomass in the seed culture stage to produce an inoculum; b) transferring the inoculum into a fermentation medium in the main fermentation stage; and, c) maintaining steady stage conditions in the main fermentation stage, thereby producing a fermentation broth containing mevinolin. Preferably, the steady state conditions are maintained in the main fermentation stage by one or more of feeding of organic carbon sources; controlling glucose and/or total reducing sugar content; feeding of organic nitrogen sources; controlling pH; controlling foam level; controlling the mass of the fermentation broth by withdrawals and feedings; and, controlling the dissolved oxygen level.
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