Method to produce novel polyketides
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United States of America Patent
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-
Dec 31, 2002
Grant Date -
N/A
app pub date -
May 14, 1999
filing date -
Jul 6, 1995
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
Modified PKS gene clusters which produce novel polyketides in an efficient system in a host cell or in a cell free extract are described. The novel polyketides result from the incorporation of diketides of the formula ##STR1## wherein A is a moiety that activates the diketide, and at least one of R.sup.1 and R.sup.2 is a substituent other than that natively occurring in the diketide normally processed by the modified PKS cluster. The polyketides may also be glycosylated to provide antibiotics.
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