Tissue engineered blood vessels and methods and apparatus for their manufacture
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United States of America Patent
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Jan 7, 2003
Issued Date -
N/A
app pub date -
Nov 22, 1999
filing date -
Nov 22, 1999
priority date (Note) -
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Abstract
The invention is a tissue engineered blood vessel (TEBV) made from a cultured fibroblast sheet rolled into a multilayer vessel which has sufficient burst strength to withstand physiological blood pressure without the inclusion of smooth muscle cells or synthetic scaffolding. The TEBV is made in a bioreactor having an enclosed chamber, a sheet growth module, a rollable mandrel and a clamp for holding the sheet to the mandrel for rolling.
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