Chemically specific imaging of tissue
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United States of America Patent
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Jan 7, 2003
Grant Date -
Apr 11, 2002
app pub date -
Jan 13, 2000
filing date -
Jan 13, 1999
priority date (Note) -
Expired
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Abstract
Disclosed are methods and materials for obtaining spatially resolved images of specific types of tissues. The method for imaging tissue comprises administering to the tissue a deuterated imaging agent and performing spectroscopy, preferably Raman spectroscopy. Electromagnetic radiation, such as a near infrared laser beam, is directed to a tissue of interest. The radiation can be scanned across and within the tissue of interest. When used in combination with a light collection system, it is possible to map out a specific volume of tissue, obtaining information regarding the distribution of specific endogenous chemical species. In some embodiments, specific imaging agents are employed to impart contrast between chemically different types of tissues.
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