Polyketide synthase genes from Streptomyces venezuelae
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United States of America Patent
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Jan 7, 2003
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N/A
app pub date -
Aug 28, 1998
filing date -
May 28, 1998
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Abstract
Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for picromycin. The combinatorial library is useful as a source of pharmaceutically active compounds. In addition, novel polyketides and antibiotics are prepared using this method.
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