Deuterated rapamycin compounds, methods and uses thereof
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United States of America Patent
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Jan 7, 2003
Grant Date -
Mar 7, 2002
app pub date -
Nov 16, 2001
filing date -
Sep 5, 1997
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The synthesis of deuterated analogues of rapamycin is disclosed together with a method for use for inducing immunosupression and in the treatment of transplantation rejection, graft vs host disease, autoimmune diseases, diseases of inflammation leukemia/lymphoma, solid tumors, fungal infections, hyperproliferative vascular disorders. Also described is a method for the synthesis of water soluble deuteratred rapamycin compounds and their use as described above.
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