Genetic inhibition by double-stranded RNA
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United States of America Patent
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Jan 14, 2003
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app pub date -
Dec 18, 1998
filing date -
Dec 23, 1997
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Abstract
A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
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