Nasal transmucosal delivery of peptide conjugated with biocompatible polymers
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United States of America Patent
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Jan 14, 2003
Grant Date -
N/A
app pub date -
Aug 15, 2000
filing date -
Aug 17, 1999
priority date (Note) -
Expired
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Abstract
The present invention relates to a pharmaceutical composition for the nasal transmucosal delivery of a biocompatible polymer-biologically active peptide conjugate. The pharmaceutical composition of the present invention increases the water solubility of peptide, which is sparingly soluble in water, improves its stability by protecting it from being degraded by proteases. As a result, the number of administrations of the drug and the side-effects induced by drug abuse are decreased. In addition, since the pharmaceutical composition of the present invention is delivered through the nasal cavity, it allows drug activity to be expressed in a short period of time and improves a bioavailability.
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