Aqueous solubility pharmaceutical formulations
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United States of America Patent
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Jan 28, 2003
Grant Date -
Mar 28, 2002
app pub date -
Jun 21, 2001
filing date -
Mar 24, 1999
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A formulation of a sparingly water-soluble, crystalline pharmaceutically active agent wherein the active agent is converted to and stabilized in its amorphous form as a solid solution of a normally hydrophobic vehicle is described. The amorphous state is stabilized by the composition of the formulation, providing long shelf life of the improved composition. This stabilized formulation also provides increased solubility and bioavailability of the active agent. Solutions of the active agent are stabilized by the composition, preventing recrystallization and precipitation of the less soluble, crystalline form of the active agent from aqueous solutions thereof.
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