Class of cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof
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United States of America Patent
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Jan 28, 2003
Grant Date -
N/A
app pub date -
Aug 24, 2000
filing date -
Sep 8, 1999
priority date (Note) -
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Abstract
The present invention provides the compound having the formula: ##STR1## wherein each of R.sub.1 and R.sub.2 is, substituted or unsubstituted, aryl, cycloalkyl, cycloalkylamino, naphtha, pyridineamino, piperidino, t-butyl, aryloxy, arylalkyloxy, or pyridine group; wherein A is an amido moiety, --O--, --S--, --NH--, or --CH.sub.2 --; and wherein n is an integer from 3 to 8. The present invention also provides a method of selectively inducing growth arrest, terminal differentiation and/or apoptosis of neoplastic cells and thereby inhibiting proliferation of such cells. Moreover, the present invention provides a method of treating a patient having a tumor characterized by proliferation of neoplastic cells. Lastly, the present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically acceptable amount of the compound above.
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