Processes for coupling amino acids using bis-(trichloromethyl) carbonate
Number of patents in Portfolio can not be more than 2000
United States of America Patent
Stats
-
Jan 28, 2003
Issued Date -
N/A
app pub date -
Jan 9, 2001
filing date -
Jul 12, 1998
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
A process is disclosed for using triphosgene as an efficient and effective coupling reagent during peptide synthesis, by in situ generation of amino acid chloride from a protected amino acid. This process is particularly useful for the coupling to sterically hindered amino acid residues, or for other difficult couplings. Furthermore, the same reagent can be used for the derivatization of peptides by formation of an amide bond between a free amine on a peptide and a carboxylic acid, or for the coupling of an amino acid to a solid support.
First Claim
Family
International Classification(s)
Cited Art Landscape
Patent Citation Ranking
Advertisement
Advertisement
Advertisement
Recipient Email Address
Recipient Email Address
Comment
Recipient Email Address
Add to Portfolio(s)
To add this patent to one, or more, of your portfolios, simply click the add button.
This Patent is in these Portfolios:
Add to additional portfolios:
Last Refreshed On:
Changes done successfully