Hydrolytically degradable carbamate derivatives of poly(ethylene glycol)
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United States of America Patent
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Feb 4, 2003
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app pub date -
Apr 26, 2001
filing date -
Dec 23, 1999
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Abstract
Poly(ethylene glycol) carbamate derivatives useful as water-soluble pro-drugs are disclosed. These degradable poly(ethylene glycol) carbamate derivatives also have potential applications in controlled hydrolytic degradation of hydrogels. In such degradable hydrogels, drugs may be either trapped in the gel and released by diffusion as the gel degrades, or they may be covalently bound through hydrolyzable carbamate linkages. Hydrolysis of these carbamate linkages releases the amine drug at a controllable rate as the gel degrades.
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